Title:
【発明の名称】アミロイド沈着物を阻害するための方法および化合物
Document Type and Number:
Japanese Patent JP2003500350
Kind Code:
A
Abstract:
Methods and compositions which are useful in the treatment of amyloidosis. In particular, methods and compositions are provided for inhibiting, preventing and treating amyloid deposition, e.g., in pancreatic islets, wherein the amyloidotic deposits are islet amyloid polypeptide (IAPP)-associated amyloid deposition or deposits. The methods of the invention involve administering to a subject a therapeutic compound which inhibits IAPP-associated amyloid deposits. Accordingly, the compositions and methods of the invention are useful for inhibiting IAPP-associated amyloidosis in disorders in which such amyloid deposition occurs, such as diabetes.
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Inventors:
Suzalek Walter A.
Weber Donald E.
Konshanki
Gupta Ajay
Mignault David
Weber Donald E.
Konshanki
Gupta Ajay
Mignault David
Application Number:
JP2000619408A
Publication Date:
January 07, 2003
Filing Date:
May 24, 2000
Export Citation:
Assignee:
Queens University at Kingston
Neurochem Incorporated
Neurochem Incorporated
International Classes:
A61K45/00; A61K31/00; A61K31/185; A61K31/192; A61K31/194; A61K31/198; A61K31/205; A61K31/4015; A61K31/403; A61K31/4035; A61K31/4152; A61K31/428; A61K31/437; A61K31/44; A61K31/4409; A61K31/4418; A61K31/4439; A61K31/445; A61K31/4453; A61K31/465; A61K31/47; A61K31/4709; A61K31/472; A61K31/4725; A61K31/473; A61K31/4741; A61K31/675; A61K31/706; A61P1/18; A61P3/10; (IPC1-7): A61K45/00; A61K31/185; A61K31/192; A61K31/194; A61K31/47; A61K31/4709; A61K31/472; A61K31/4725; A61K31/473; A61K31/4741; A61K31/675; A61K31/706; A61P1/18; A61P3/10
Domestic Patent References:
| JPH0995444A | 1997-04-08 |
Foreign References:
| WO1999008685A1 | 1999-02-25 |
Attorney, Agent or Firm:
Shimizu Hatsushi (1 person outside)