Title:
【発明の名称】高い結合活性の多価および多特異的試薬
Document Type and Number:
Japanese Patent JP2001521496
Kind Code:
A
Abstract:
This application provides polyvalent or polyspecific protein complexes, comprising three or more polypeptides which associate to form three or more functional target-binding regions (TBRs), and in which each individual polypeptide comprises two or more immunoglobulin-like domains which are covalently joined together, such that two Ig-like domains in a single polypeptide do not associate with each other to form a TBR. By using a linker peptide of fewer than three amino acid residues the immunoglobulin-like domains of the individual polypeptides are prevented from associating, so that complex formation between polypeptides is favoured. Preferably the polyvalent or polyspecific protein is a trimer or tetramer. The proteins of the application have specifities which may be the same or different, and are suitable for use as therapeutic, diagnostic or imaging agents.
Inventors:
Hudson, Peter John
Colt, Alex Andrew
Irving, robert alexander
Atwell, John Leslie
Colt, Alex Andrew
Irving, robert alexander
Atwell, John Leslie
Application Number:
JP54099398A
Publication Date:
November 06, 2001
Filing Date:
March 26, 1998
Export Citation:
Assignee:
Commonwealth Scientific and Industrial Research Organization
International Classes:
C12N15/09; A61K39/395; A61K47/48; A61K51/00; C07K14/705; C07K16/00; C07K16/40; C07K16/42; C12N15/13; A61K38/00; (IPC1-7): C07K16/00; A61K39/395; A61K47/48; A61K51/00
Attorney, Agent or Firm:
Takashi Ishida (4 others)