Title:
【発明の名称】マトリクス金属プロテイナーゼ阻害薬としてのN-ヒドロキシ-2-(アルキル、アリールまたはヘテロアリールスルファニル、スルフィニルまたはスルホニル)-3-置換-アルキル、アリールまたはヘテロアリールアミド
Document Type and Number:
Japanese Patent JP2002503717
Kind Code:
A
Abstract:
Matrix metalloproteinases (MMPs) are a group of enzymes that have been implicated in the pathological destruction of connective tissue and basement membranes. These zinc containing endopeptidases consist of several subsets of enzymes including collagenases, stromelysins and gelatinases. TNF- alpha converting enzyme (TACE), a pro-inflammatory cytokine, catalyzes the formation of TNF- alpha from membrane bound TNF- alpha precursor protein. It is expected that small molecule inhibitors of MMPs and TACE therefore have the potential for treating a variety of disease states. The present invention provides low molecular weight, non-peptide inhibitors of matrix metalloproteinases (MMPs) and TNF- alpha converting enzyme (TACE) for the treatment of arthritis, tumor metastasis, tissue ulceration, abnormal wound healing, periodontal disease, bone disease, diabetes (insulin resistance) and HIV infection having formula (I), wherein R<2> and R<3> form a heterocyclic ring and A is S, S(O), or S(O)2 and R<1> and R<4> are defined herein.
Inventors:
Alana Pacum Mudanbai Bencatesan
George Theodore Gross
Jamie Marie Davis
Janie Lee Baker
Jeremy Ian Levin
George Theodore Gross
Jamie Marie Davis
Janie Lee Baker
Jeremy Ian Levin
Application Number:
JP2000532389A
Publication Date:
February 05, 2002
Filing Date:
August 26, 1998
Export Citation:
Assignee:
American Cyanamid Company
International Classes:
A61K31/16; A61K31/351; A61K31/381; A61K31/403; A61K31/4035; A61K31/423; A61K31/426; A61K31/428; A61K31/4406; A61K31/4418; A61K31/4427; A61K31/4433; A61K31/4436; A61K31/445; A61K31/4453; A61K31/4458; A61K31/4535; A61K31/454; A61K31/4545; A61K31/47; A61K31/5375; A61K31/5377; A61K31/55; A61P1/02; A61P1/04; A61P1/16; A61P7/02; A61P9/00; A61P9/10; A61P13/12; A61P15/06; A61P17/00; A61P17/02; A61P19/02; A61P19/08; A61P27/02; A61P29/00; A61P35/00; A61P35/04; A61P43/00; C07C259/06; C07C317/44; C07C323/60; C07D207/12; C07D209/48; C07D211/12; C07D211/20; C07D211/54; C07D211/62; C07D211/66; C07D213/56; C07D215/12; C07D223/02; C07D241/04; C07D263/58; C07D277/20; C07D277/36; C07D277/70; C07D295/08; C07D295/092; C07D307/54; C07D309/12; C07D333/28; C07D333/34; C07D401/10; C07D409/04; C07D409/10; (IPC1-7): C07C259/06; A61K31/16; A61K31/351; A61K31/381; A61K31/4035; A61K31/423; A61K31/426; A61K31/428; A61K31/4406; A61K31/4436; A61K31/445; A61K31/4453; A61K31/4458; A61K31/4535; A61K31/454; A61K31/4545; A61K31/47; A61K31/5375; A61K31/5377; A61K31/55; A61P1/02; A61P1/04; A61P1/16; A61P7/02; A61P9/00; A61P9/10; A61P13/12; A61P15/06; A61P17/00; A61P17/02; A61P19/02; A61P19/08; A61P27/02; A61P29/00; A61P35/00; A61P35/04; A61P43/00; C07C317/44; C07C323/60; C07D207/12; C07D209/48; C07D211/12; C07D211/66; C07D213/56; C07D215/12; C07D223/02; C07D241/04; C07D263/58; C07D277/36; C07D277/70; C07D295/08; C07D307/54; C07D309/12; C07D333/28; C07D333/34; C07D401/10; C07D409/04; C07D409/10
Domestic Patent References:
| JPH11199512A | 1999-07-27 | |||
| JP2001523662A | 2001-11-27 | |||
| JP2001519777A | 2001-10-23 | |||
| JP2001513771A | 2001-09-04 | |||
| JPH06256293A | 1994-09-13 | |||
| JPH10501806A | 1998-02-17 | |||
| JPH09508362A | 1997-08-26 |
Attorney, Agent or Firm:
Aoyama Ryo (1 person outside)