Title:
【発明の名称】光学活性カンプトテシン誘導体及びその製法
Document Type and Number:
Japanese Patent JP3126799
Kind Code:
B2
Abstract:
PURPOSE:To obtain the subject derivative having excellent optical purity due to no side reaction under mild conditions and useful as a synthetic intermediate, etc., for synthetic anticancer agents, etc., by reacting a specific racemic modifica tion with a SH enzyme. CONSTITUTION:A racemic modification (preferably in the concentration of 0.1-0.2wt.%) of 20-O-acyl-7-ethyl-10-methoxycamptothecin of formula I (RCO is acyl) is made to react with an SH enzyme derived from a plant or an animal, preferably in an amount of 1-50 times by weight based on the racemic modification to provide the objective derivative of formula II.
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Inventors:
Akihiko Miyadera
Akihiro Imura
Akihiro Imura
Application Number:
JP7697892A
Publication Date:
January 22, 2001
Filing Date:
March 31, 1992
Export Citation:
Assignee:
Daiichi Pharmaceutical Co., Ltd.
Yakult Honsha Co., Ltd.
Yakult Honsha Co., Ltd.
International Classes:
C07D491/22; C12N9/04; C12N9/48; C12P41/00; (IPC1-7): C07D491/22; C12P41/00
Attorney, Agent or Firm:
Miyuki Ariga (2 outside)