Title:
【発明の名称】毒性ショック症候群および敗血症性ショックの兆候を減少させるのに有用なペプチド
Document Type and Number:
Japanese Patent JP2003517445
Kind Code:
A
Abstract:
This invention relates to compositions and methods which provide protection against, or reduce the severity of toxic shock and septic shock from bacterial infections. More particularly it relates to peptides derived from homologous sequences of the family of staphylococcal and streptococcal toxins, which may be polymeric, and carrier-conjugates thereof. The invention also relates to serum antibodies induced by the peptides and carrier-conjugates and their use to prevent, treat, or protect against the toxic effects of most, if not all, of the staphylococcal and streptococcal toxins. The invention also relates to diagnostic assays and kits to detect the presence of staphylococcal and streptococcal toxins, or antibodies thereto. The invention also relates isolated and purified to nucleic acids encoding the peptides of the invention and transformed host cells containing those nucleic acids.
Inventors:
Bannan, Jason Dee
Wisvanathan, Kumar
Zabriskie, John Bee
Wisvanathan, Kumar
Zabriskie, John Bee
Application Number:
JP2000574693A
Publication Date:
May 27, 2003
Filing Date:
September 24, 1999
Export Citation:
Assignee:
The Rockefeller University
International Classes:
G01N33/50; A61K38/00; A61P31/04; A61P39/02; A61P43/00; C07K4/04; C07K14/31; C07K14/315; C07K16/12; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/09; C12N15/31; G01N33/15; G01N33/569; A61K39/00; (IPC1-7): C07K4/04; A61K38/00; A61P31/04; A61P39/02; A61P43/00; C07K14/315; C07K16/12; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/09; G01N33/15; G01N33/50; G01N33/569
Attorney, Agent or Firm:
Kazuo Shamoto (4 outside)