Title:
【発明の名称】N-(3-ヒドロキシ-スクシニル)-アミノ酸誘導体調製のためのプロセス
Document Type and Number:
Japanese Patent JP2001517225
Kind Code:
A
Abstract:
Processes for preparing compounds of the formula (I) are described: P1OOC-CH(OH)-CHR1-CONH-Z wherein P1 is hydrogen or a protecting group, Z is a group -CHR2COOP2 or -CHR2CONR3R4 wherein P2 is hydrogen or a protecting group and R1-R4 are values known in the TNF-inhibitor art. The compounds of the formula (I) are useful in inhibiting TNF and one or more matrix metalloproteinase enzymes. One intermediate in a process of the invention is formula (II).
Inventors:
Bird, Thomas Geofree Colric
Pasque, Mari-Gennes
Pelter, jack
Pasque, Mari-Gennes
Pelter, jack
Application Number:
JP54128798A
Publication Date:
October 02, 2001
Filing Date:
March 25, 1998
Export Citation:
Assignee:
Geneca Limited
Geneca Pharma S.a.
Geneca Pharma S.a.
International Classes:
C07C55/32; C07C69/63; C07C231/02; C07C231/14; C07C235/12; C07C237/22; C07C259/06; C07C309/63; C07D305/12; C07C235/22; (IPC1-7): C07C231/02; C07C55/32; C07C69/63; C07C235/12; C07C237/22; C07C259/06; C07D305/12
Attorney, Agent or Firm:
Shusaku Yamamoto