Title:
【発明の名称】C‐1に極性エステル基を有するプロスタグランジン‐F▲下2▼αの1,11‐ジエステル
Document Type and Number:
Japanese Patent JPH09504029
Kind Code:
A
Abstract:
Compounds of the formula where the hatched lines indicate alpha ( alpha ) configuration, a solid triangle is used to indicate beta ( beta ) configuration, lines on both sides of a double bond indicate cis (Z) configuration, and lines on opposite sides of the double bond indicate trans (E) configuration; R1 is alkyl of 1-10 carbons, C1-C10alkylphenyl, phenyl-C1-C10alkyl, or alkenyl of 2 to 10 carbons and having 1 to 3 double bonds; R2 is Z-OR3, Z-OCOR3, Z-OCONHR3, Z-OCOOR3, Z-NR4R5, Z-NR4COR3, Z-NR4SO2R3, Z-COOR3, Z-CONR4R5, Z-CHO; Z is (CH2)n where n is 1-6, or Z is an alkenyl group having 2 to 6 carbons and 1 or 2 double bonds, R3 is H, alkyl of 1-6 carbons, alkenyl of 2 to 6 carbons or phenyl, R4 and R5 independently are H or alkyl of 1 to 6 carbons, have ocular hypotensive activity.
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Inventors:
Gerst Michael Yee
Sage Elizabeth Tee
Roof michael bee
Woodward David F
Chang Min Phi
Sage Elizabeth Tee
Roof michael bee
Woodward David F
Chang Min Phi
Application Number:
JP51216395A
Publication Date:
April 22, 1997
Filing Date:
October 17, 1994
Export Citation:
Assignee:
Allergan
International Classes:
A61K31/557; A61K31/5575; A61P27/02; C07C405/00; (IPC1-7): C07C405/00; A61K31/557
Attorney, Agent or Firm:
Minoru Nakamura (7 outside)