Title:
【発明の名称】プロテインキナーゼCのビス―(ヒドロキシアルキルアミノ)―アントラキノン阻害剤
Document Type and Number:
Japanese Patent JPH05503721
Kind Code:
A
Abstract:
PCT No. PCT/US91/08026 Sec. 371 Date Jun. 8, 1992 Sec. 102(e) Date Jun. 8, 1992 PCT Filed Oct. 30, 1991 PCT Pub. No. WO92/07557 PCT Pub. Date May 14, 1992. ( alpha ) The present invention provides novel substituted anthraquinones having formula ( alpha ), wherein R1 and R2 are independently H, C1-C10 alkyl, aryl, arylalkyl, alkylaryl, or R1 and R2 taken together with the adjacent nitrogen atom N form a substituted or unsubstituted cyclic ring which may contain additional heteroatoms; n and m are independently 1, 2, or 3; A is halogen, OH, alkoxy, OCO(NR3R4), S-C(NH2)=NR5, or when m=1, comprises an oxirane ring with the adjacent oxygen atom; R3, R4, and R5 are independently H, alkyl, or aryl; X is H, OH, NR6R7, Cl, Br, I, F, alkyl, aryl, alkoxy, aryloxy, COOR8, or CONR9R10; and R6, R7, R8, R9, and R10 are independently H, lower alkyl, or aryl useful for inhibiting protein kinase C and treating conditions related to, or affected by inhibition of protein kinase C, particularly cancer tumors, inflammatory disease, reperfusion injury, and cardiac dysfunctions related to reperfusion injury.
Inventors:
Jean, Jack Bee
Johnson, Mary George
Johnson, Mary George
Application Number:
JP50087092A
Publication Date:
June 17, 1993
Filing Date:
October 30, 1991
Export Citation:
Assignee:
Sphinx Farmers-Tikal's Corporation
International Classes:
A61K31/135; A61K31/155; A61K31/165; A61K31/235; A61K31/27; A61K31/335; A61K31/336; A61P35/00; A61P43/00; C07C225/34; C07C225/36; C07C229/74; C07C271/10; C07C271/12; C07C271/42; C07C335/32; C07D303/36; (IPC1-7): A61K31/135; A61K31/155; A61K31/165; A61K31/235; A61K31/27; A61K31/335; C07C225/34; C07C271/10; C07C271/42; C07C335/32; C07D303/36
Attorney, Agent or Firm:
Kyozo Yuasa (6 people outside)