Title:
【発明の名称】エストロゲンレセプターモジュレーターとしてのピラゾール
Document Type and Number:
Japanese Patent JP2002522422
Kind Code:
A
Abstract:
Estrogen receptor-modulating pyrazole compounds are described in addition to methods and compositions for treating or preventing estrogen receptor-mediated disorders. The compounds described have been found to have unexpected and surprising activity in modulating estrogen receptor activity. Thus, the compounds of the present invention have utility in preventing or treating estrogen receptor-mediated disorders such as osteoporosis, breast and endometrial cancers, atherosclerosis, and Alzheimer's disease.
Inventors:
Huebner, Berena Dee.
Lynn, Xiao Dong
James, ian
Chain, rear
Desai, Manoji
Cryult, beata
Shin, Razinder
Wang, Liang
Lynn, Xiao Dong
James, ian
Chain, rear
Desai, Manoji
Cryult, beata
Shin, Razinder
Wang, Liang
Application Number:
JP2000563630A
Publication Date:
July 23, 2002
Filing Date:
August 06, 1999
Export Citation:
Assignee:
Chiron Corporation
International Classes:
A61K31/415; A61K31/4155; A61K31/416; A61K31/4427; A61K31/4433; A61K31/454; A61K31/498; A61K31/5377; A61P5/32; A61P19/10; A61P25/28; A61P35/00; C07D231/12; C07D231/54; C07D231/56; C07D261/08; C07D261/10; C07D261/18; C07D261/20; C07D401/04; C07D401/06; C07D403/04; C07D409/04; C07D413/04; C07D413/12; C07D471/04; C07D498/04; (IPC1-7): C07D231/12; A61K31/415; A61K31/4155; A61K31/416; A61K31/4427; A61K31/454; A61K31/498; A61K31/5377; A61P5/32; A61P19/10; A61P25/28; A61P35/00; C07D231/56; C07D401/06; C07D409/04; C07D413/04; C07D471/04
Other References:
JPN6009060541, ＥＵＲ． Ｊ． ＭＥＤ． ＣＨＥＭ, 1994, ２９（１）, ｐｐ．２５−３２
JPN6009060544, Ｊｏｕｒｎａｌ ｏｆ ｔｈｅ Ｃｈｅｍｉｃａｌ Ｓｏｃｉｅｔｙ， Ｐｅｒｋｉｎ Ｔｒａｎｓａｃｔｉｏｎｓ １： Ｏｒｇａｎｉｃ ａｎｄ Ｂｉｏ−Ｏｒｇａｎｉｃ Ｃｈｅｍｉｓｔｒｙ, 1981, ｖｏｌ．７, ｐｐ．１８９１−１８９５
JPN6009060544, Ｊｏｕｒｎａｌ ｏｆ ｔｈｅ Ｃｈｅｍｉｃａｌ Ｓｏｃｉｅｔｙ， Ｐｅｒｋｉｎ Ｔｒａｎｓａｃｔｉｏｎｓ １： Ｏｒｇａｎｉｃ ａｎｄ Ｂｉｏ−Ｏｒｇａｎｉｃ Ｃｈｅｍｉｓｔｒｙ, 1981, ｖｏｌ．７, ｐｐ．１８９１−１８９５
Attorney, Agent or Firm:
Shusaku Yamamoto