Title:
【発明の名称】酵素阻害薬としての,ピリミジン,ピリジン,プテリジノンおよびインダゾール誘導体
Document Type and Number:
Japanese Patent JPH08504798
Kind Code:
A
Abstract:
The use of a compound which binds at the tetrahydrobiopterin site of NO synthase for the treatment of conditions where there is an advantage in inhibiting neuronal NO synthase with little or no inhibition of endothelial NO synthase is disclosed. Pharmaceutical formulations comprising such compounds, and processes, including a novel process, for their preparation are also disclosed.
Inventors:
Big Ham, Eric Cleveland
Rainhard, John Frederick, Junior
Moore, Philip Case
Babbage, Rachel Cecilia
Knowles, Richard Graham
Nobs, Malcolm Stewart
Bull, donald
Rainhard, John Frederick, Junior
Moore, Philip Case
Babbage, Rachel Cecilia
Knowles, Richard Graham
Nobs, Malcolm Stewart
Bull, donald
Application Number:
JP51490993A
Publication Date:
May 21, 1996
Filing Date:
December 15, 1993
Export Citation:
Assignee:
The Welcome Foundation Limited
International Classes:
A61K31/415; A61K31/44; A61K31/4418; A61K31/443; A61K31/4433; A61K31/47; A61K31/495; A61K31/505; A61K31/517; A61K31/519; A61K31/53; A61P43/00; C07D213/73; C07D253/06; C07D213/75; C07D231/56; C07D239/42; C07D239/46; C07D239/48; C07D239/70; C07D405/04; C07D409/04; C07D475/04; (IPC1-7): A61K31/44; A61K31/415; A61K31/505; A61K31/53; C07D213/73; C07D231/56; C07D239/42; C07D239/46; C07D239/70; C07D253/06; C07D405/04; C07D409/04; C07D475/04
Attorney, Agent or Firm:
Akira Asamura (3 outside)