Title:
【発明の名称】人体への17―β―エストラジオールの放出のための皮膚貼着製剤、特に経皮性治療システム
Document Type and Number:
Japanese Patent JP2000505071
Kind Code:
A
Abstract:
A pharmaceutical preparation adhering to the skin, in particular a TTS, for the release of the active substance 17-beta-estradiol, the concentration of the estradiol contained therein in dissolved form being between its saturation concentration in equilibrium with a gas phase of less than 10% relative air humidity and its saturation concentration in equilibrium with a gas phase of more than 90% relative air humidity, in all matrix layers and, if present, also in an adhesive layer, characterized in that the estradiol quantity contained in the preparation amounts to at least three times the saturation solubility measured at 95% relative air humidity, and that the air enclosed in the package is adjusted to a relative air humidity between 5% and below 0.5%.
Inventors:
Asmussen, board
Horstmann, Michael
Horstmann, Michael
Application Number:
JP52481397A
Publication Date:
April 25, 2000
Filing Date:
December 23, 1996
Export Citation:
Assignee:
LTS Roman Therapy-Sute Steme Game Behr
International Classes:
A61K9/70; A61K31/00; A61K31/565; A61L15/44; A61P5/30; A61L15/58; A61P19/00; A61P19/10; (IPC1-7): A61K31/565; A61K9/70; A61P5/30; A61P19/10; A61L15/58
Attorney, Agent or Firm:
Hiroyuki Ikeuchi (2 outside)