Title:
【発明の名称】脳神経変性性疾患治療剤
Document Type and Number:
Japanese Patent JP3089040
Kind Code:
B2
Abstract:
A therapeutic agent for alleviating disorders caused by nerve cell degeneration in the brain which contains a cyclopropachromen derivative represented by the following general formula (I): wherein n is an integer of from 2 to 5; the carbon atom in the -(CH2)n- moiety may be optionally substituted with a methyl group or a hydroxyl group; R<1> and R<2> independently represent a hydrogen atom, an alkyl group having 1 to 5 carbon atoms, a phenyl group or an aralkyl group having 7 to 10 carbon atoms; or alternatively R<1> and R<2> form together with the nitrogen atom to which they are attached, a morpholino group, a thiomorpholino group, a pyrrolidinyl group, a piperidinyl group, a homopiperidinyl group, a piperazinyl group, a homopiperazinyl group, an N-alkylpiperazinyl group, N-alkylhomopiperazinyl group, an N-hydroxyalkylpiperazinyl group or a pyrrolidonyl group or alternatively R<1> and R<2> form together with the nitrogen atom to which they are attached, and further a carbon atom to which said nitrogen atom is bound, a pyrrolitidinyl group; A<1> and A<2> independently represent a hydrogen atom, a hydroxyl group, a halogen atom, an optionally halogenated alkyl group having 1 to 5 carbon atoms, an optionally substituted alkoxy group, an acyloxy group, a carbamyloxy group or an optionally substituted carboxyl group; and B<1> and B<2> independently represent a hydrogen atom, a halogen atom, a nitro group, a cyano group, an optionally halogenated alkyl group having 1 to 5 carbon atoms, an alkoxy group having 1 to 5 carbon atoms or an optionally substituted carboxyl group; or a pharmaceutically acceptable salt thereof as an active ingredient, together with a pharmaceutical carrier or adjuvant.
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Inventors:
Toshio Tateoka
Kayoko Nomura
Yuzo Nakagawa
Shizuo Nakamura
Kayoko Nomura
Yuzo Nakagawa
Shizuo Nakamura
Application Number:
JP3303191A
Publication Date:
September 18, 2000
Filing Date:
February 27, 1991
Export Citation:
Assignee:
Suntory Limited
International Classes:
A61K31/35; A61K31/40; A61K31/445; A61K31/495; A61K31/535; A61K31/54; A61P25/28; C07D311/94; C07D315/00; (IPC1-7): A61K31/35; A61P25/28
Domestic Patent References:
| JP62198676A |
Attorney, Agent or Firm:
Kazuo Shamoto (5 outside)