Title:
【発明の名称】1,2―エタンジオール誘導体およびその塩
Document Type and Number:
Japanese Patent JP2887492
Kind Code:
B2
Abstract:
NEW MATERIAL:The compound of formula I [R<1> is (substituted) heterocyclic group; R<2> is H, lower alkyl or OH-protecting group; R<3> is H or lower alkyl; nXR<4> and R<5> groups are same or different H or lower alkyl; R<6> is (substituted) amino or nitrogen-containing heterocyclic group or ammonio; (n) is 0-6] and its salt. EXAMPLE:2-[2-(N,N-dimethylamino)ethoxy]-1-(benzo[b]thiophen-5-yl)ethanol. USE:It has excellent anti-amnesic action and antihypoxic action and is extremely useful as a cerebral function improver. It is useful not only as a treating agent for the sequela of ischemic cerebral disorder and cerebral apoplexy but also as a therapeutic agent or preventive for amnesia and dementia. PREPARATION:The objective compound of formula I wherein R<2> is H or its salt can be produced e.g. by reacting a compound of formula II with a compound of formula III or its salt.
Inventors:
ONO SATORU
SANTO TETSUO
CHAKI HISAAKI
MAEKAWA MUTSUKO
TODO YOZO
NARITA HIROKAZU
SANTO TETSUO
CHAKI HISAAKI
MAEKAWA MUTSUKO
TODO YOZO
NARITA HIROKAZU
Application Number:
JP2450390A
Publication Date:
April 26, 1999
Filing Date:
February 05, 1990
Export Citation:
Assignee:
TOYAMA KAGAKU KOGYO KK
International Classes:
A61K31/34; A61K31/341; A61K31/343; A61K31/38; A61K31/381; A61K31/395; A61K31/4025; A61K31/403; A61K31/404; A61K31/405; A61K31/415; A61K31/4184; A61K31/44; A61K31/4427; A61K31/4433; A61K31/445; A61K31/454; A61K31/47; A61K31/495; A61K31/496; A61K31/535; A61K31/5355; A61P9/10; A61P25/28; C07D209/04; C07D209/14; C07D209/34; C07D213/38; C07D213/64; C07D213/74; C07D215/12; C07C31/20; C07D233/64; C07D235/04; C07D241/06; C07D307/52; C07D307/81; C07D333/28; C07D333/58; C07D401/12; C07D409/12; C07D413/12; C07D453/02; C07D521/00; (IPC1-7): C07D213/38; A61K31/34; A61K31/38; A61K31/395; A61K31/405; A61K31/415; A61K31/44; A61K31/445; A61K31/47; A61K31/495; A61K31/535; C07D209/04; C07D209/14; C07D209/34; C07D213/64; C07D213/74; C07D215/12; C07D233/64; C07D235/04; C07D241/06; C07D307/52; C07D307/81; C07D333/28; C07D333/58; C07D401/12; C07D409/12; C07D413/12; C07D453/02; C07D521/00
Domestic Patent References:
| JP3197422A | ||||
| JP347158A |
Other References:
【文献】国際公開88/8424(WO,A1)
【文献】Chemical Abstracts 抄録番号 109:129471(1988年)
【文献】Chemical Abstracts 抄録番号 109:129471(1988年)
Attorney, Agent or Firm:
Kazuo Kumada