Title:
【発明の名称】1,4―ジヒドロピリジン―エナンチオマーおよびその製法
Document Type and Number:
Japanese Patent JP2625190
Kind Code:
B2
Abstract:
PCT No. PCT/EP88/00239 Sec. 371 Date Sep. 19, 1989 Sec. 102(e) Date Sep. 19, 1989 PCT Filed Mar. 24, 1988 PCT Pub. No. WO88/07525 PCT Pub. Date Oct. 6, 1988.Enantiomerically-pure dihydropyridines of formula I (I) are effective vasodilators useful for treating coronary diseases. They have particularly advantageous properties with regard to extent and controllability of blood pressure lowering, a surprisingly small (and for repeated administration-vanishing) increase in heart rate, excellent bioavailability, high therapeutic index, lack of central side effects, lack of kinetic interactions with other substances, absence of tolerance development, well-balanced physical properties and high stability. A new process for preparing these compounds is also presented.
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Inventors:
Ulrich, Wolff-Rieuger
Am Schiler, Hermann
Frotzkel Twi, Dater
Klemm, Kurt
Cole, Bernhard
Aisut Tetter, Claus
Erzewe, Manfleet
Collatsa, Norbert
Carl, Zanders
Christian, Christian
Am Schiler, Hermann
Frotzkel Twi, Dater
Klemm, Kurt
Cole, Bernhard
Aisut Tetter, Claus
Erzewe, Manfleet
Collatsa, Norbert
Carl, Zanders
Christian, Christian
Application Number:
JP50348488A
Publication Date:
July 02, 1997
Filing Date:
March 24, 1988
Export Citation:
Assignee:
Bijk Gruden Romberg Hiermitzie Hua Creek Gezershyaft Mitt Beth Yulenktel Haftung
International Classes:
A61K31/44; A61K31/4427; A61K31/443; A61K31/4433; A61K31/495; A61P9/08; A61P9/12; C07D211/90; C07D401/04; C07D401/12; C07D405/04; C07D405/12; C07D409/04; C07D413/04; C07D413/14; C07D417/04; (IPC1-7): C07D211/90; C07D401/04
Domestic Patent References:
| JP6185362A | ||||
| JP6013789A |
Other References:
【文献】国際公開86/3748(WO,A1)
Attorney, Agent or Firm:
Toshio Yano