Title:
【発明の名称】5-リポキシゲナ-ゼ阻害剤としての2-置換-1-ナフト-ル類
Document Type and Number:
Japanese Patent JP2554322
Kind Code:
B2
Abstract:
2-Substituted-1-naphthols are 5-lipoxygenase inhibitors which make them useful in the treatment of inflammation, obstructive lung diseases and/or psoriasis. Useful 2-substituent groups are alkyls, alkenyls, alkynyls, cycloalkyls, cycloalkenyls, the groups CH2-C 3BOND C-(CH2)mR5 and CH=CH-(CH2)nR5 (where m is 1-4, n is 0-3 and R5 includes phenyl, COOR9, where R9 is H or alkyl of 1-4 carbons, AR6 (where A is a methylene chain and R6 is a variety of groups including Cl, Br, I, CHO, CN, COOR9, NH2, SC(NH)NH2, phenyl, P(O)(OR9)2, etc.), and CHR7R21 (where R7 is a variety of aromatic and heterocyclic groups and R21 is H, optionally substituted phenyl and a variety of heterocyclic groups).
Inventors:
DAGURASU GAI BATSUTO
Application Number:
JP10324686A
Publication Date:
November 13, 1996
Filing Date:
May 07, 1986
Export Citation:
Assignee:
DEYUHON MERUKU PHARM CO ZA
International Classes:
C12N9/99; A61K31/00; A61K31/045; A61K31/047; A61K31/05; A61K31/085; A61K31/10; A61K31/12; A61K31/135; A61K31/165; A61K31/17; A61K31/18; A61K31/19; A61K31/215; A61K31/235; A61K31/275; A61K31/415; A61K31/44; C07C39/14; C07C39/17; C07C39/18; C07C39/19; C07C39/225; C07C39/23; C07C39/38; C07C39/42; C07C43/178; C07C43/23; C07C43/295; C07C43/30; C07C49/83; C07C49/84; C07C59/42; C07C59/58; C07C59/68; C07C59/74; C07C59/76; C07C65/01; C07C65/11; C07C65/21; C07C65/24; C07C69/732; C07C69/736; C07C69/738; C07C69/94; C07C215/54; C07C215/86; C07C235/72; C07C327/44; C07C335/32; C07D207/323; C07D213/30; C07D213/50; C07D233/20; C07D277/22; C07D295/08; C07D295/096; C07D295/185; C07D307/42; C07D307/46; C07D333/16; C07D333/22; C07F7/18; C07F9/38; C07F9/40; (IPC1-7): C07C39/14; C07C39/23; C07C39/38; C07C43/23; C07C59/70; C07C69/732; C07C233/25; C07C235/66; C07C311/16; C07C317/22; C07C323/18; C07D207/323; C07D213/30; C07D307/42; C07D333/16; C07D333/22
Other References:
TETRAHEDRON LETTERS=1985
Attorney, Agent or Firm:
Chika Takagi (2 outside)