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Title:
【発明の名称】MEX阻害物質としての5-アミド置換ジアリールアミン類
Document Type and Number:
Japanese Patent JP2003527379
Kind Code:
A
Abstract:
Diarylamines, such as 5-amide substituted diarylamines of formula (I) or formula (II) wherein A is hydroxy, C1-6 alkoxy, or NR6OR7; X is OR12, NR13R12, or NR14; inhibitors of MEK and are useful in the treatment of a variety of proliferative disease states, such as conditions related to the hyperactivity of MEK, as well as diseases modulated by the MEK cascade.

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Inventors:
Byersie, Kathryn
Techle, Hale
Worms, Joseph Scott
Application Number:
JP2001567711A
Publication Date:
September 16, 2003
Filing Date:
March 12, 2001
Export Citation:
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Assignee:
WARNER-LAMBERT COMPANYLLC
International Classes:
C07D249/18; A61K31/166; A61K31/196; A61K31/337; A61K31/357; A61K31/381; A61K31/40; A61K31/4015; A61K31/4045; A61K31/415; A61K31/416; A61K31/417; A61K31/44; A61K31/4402; A61K31/4406; A61K31/4409; A61K31/445; A61K31/4453; A61K31/4741; A61K31/475; A61K31/495; A61K31/496; A61K31/498; A61K31/4985; A61K31/501; A61K31/5375; A61K31/538; A61K31/54; A61K31/662; A61P3/02; A61P5/14; A61P9/04; A61P9/10; A61P13/12; A61P17/06; A61P19/02; A61P25/04; A61P25/32; A61P29/00; A61P29/02; A61P35/00; A61P37/02; C07C237/30; C07C237/32; C07C237/34; C07C237/38; C07C237/40; C07C259/10; C07C311/46; C07C323/42; C07D207/12; C07D207/27; C07D209/16; C07D211/20; C07D211/26; C07D211/32; C07D211/42; C07D213/40; C07D213/74; C07D213/75; C07D231/40; C07D231/56; C07D233/64; C07D237/08; C07D241/04; C07D241/44; C07D263/58; C07D265/22; C07D277/04; C07D285/12; C07D285/135; C07D295/10; C07D295/13; C07D295/192; C07D307/68; C07D319/18; C07D333/36; C07D333/38; C07D333/48; C07D413/06; C07D413/12; C07D417/06; C07D417/12; C07D487/04; C07D491/048; C07D521/00; C07F9/6509; (IPC1-7): C07C237/30; A61K31/166; A61K31/196; A61K31/337; A61K31/357; A61K31/381; A61K31/40; A61K31/4015; A61K31/4045; A61K31/415; A61K31/416; A61K31/417; A61K31/44; A61K31/4402; A61K31/4406; A61K31/4409; A61K31/445; A61K31/4453; A61K31/4741; A61K31/475; A61K31/495; A61K31/496; A61K31/498; A61K31/4985; A61K31/501; A61K31/5375; A61K31/538; A61K31/54; A61K31/662; A61P3/02; A61P5/14; A61P9/04; A61P9/10; A61P13/12; A61P17/06; A61P19/02; A61P25/04; A61P25/32; A61P29/00; A61P29/02; A61P35/00; A61P37/02; C07C237/32; C07C237/34; C07C237/38; C07C237/40; C07C259/10; C07C311/46; C07C323/42; C07D207/12; C07D207/27; C07D209/16; C07D211/20; C07D211/26; C07D211/32; C07D211/42; C07D213/40; C07D213/74; C07D213/75; C07D231/40; C07D231/56; C07D233/64; C07D237/08; C07D241/04; C07D241/44; C07D249/18; C07D263/58; C07D265/22; C07D277/04; C07D285/135; C07D295/10; C07D307/68; C07D319/18; C07D333/36; C07D333/38; C07D333/48; C07D413/06; C07D413/12; C07D417/06; C07D417/12; C07D487/04; C07D491/048; C07F9/6509
Attorney, Agent or Firm:
Kazuo Shamoto (5 outside)



 
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