Title:
【発明の名称】過テクネチウム酸塩および過レニウム酸塩の還元剤としてスズイオンを使用するTcおよびReカルボニル錯体の処方
Document Type and Number:
Japanese Patent JP2003535005
Kind Code:
A
Abstract:
The invention relates to novel aminocarboxylate ligands that are suitable for complexing with a radionuclide, and are useful as therapeutic agents and as imaging agents for diagnostic purposes. In accordance with the present invention, a method of preparing a compound of formula fac-[M(CO)3(OH2)3]+ (I) where M is MN, 99mTc, 186Re or 188Re, involves reacting a metal in permetallate form with carbon monoxide and stannous ion. The compound of formula (I) can be reacted with a ligand Lx to form a compound of the formula fac-[M(CO)3Lx]n (II) wherein M is as defined above, Lx is a monodentate or multidentate ligand or a mixture of these ligands, and n is a charge of the ligand Lx increased with one+charge. The invention also is directed to novel compounds, and kits for carrying out the disclosed methods.
Inventors:
David W Pipes
Mary E. Disruski
Elizabeth G. Web
Mary E. Disruski
Elizabeth G. Web
Application Number:
JP2001585827A
Publication Date:
November 25, 2003
Filing Date:
May 08, 2001
Export Citation:
Assignee:
Mallinckrodt INC.
International Classes:
G21H5/02; A61K49/08; A61K51/00; A61K51/04; A61P43/00; C01G45/04; C01G47/00; C01G99/00; C07F5/00; C07F13/00; (IPC1-7): C01G57/00; C01G45/04; C01G47/00
Domestic Patent References:
| JP2003503415A | 2003-01-28 | |||
| JP2003511334A | 2003-03-25 | |||
| JPS55116630A | 1980-09-08 |
Foreign References:
| WO1997044110A1 | 1997-11-27 | |||
| WO1999001591A1 | 1999-01-14 | |||
| WO1998048848A1 | 1998-11-05 |
Attorney, Agent or Firm:
Aoyama Ryo (2 outside people)