Title:
【発明の名称】ポリケチドの異種産生
Document Type and Number:
Japanese Patent JP2003512073
Kind Code:
A
Abstract:
Recombinant Escherichia coli host cells that comprise recombinant DNA expression vectors that drive expression of methylmalonyl CoA mutase from Propionibacterium shermanii or Streptomyces cinnamonensis as well as Propionibacterium shermanii epimerase can produce S-methylmalonyl CoA, a required substrate for the production of polyketides by most modular polyketide synthases not present in wild-type E. coli host cells.
Inventors:
Santi, Daniel
Peck, rally
Diem, linda
Keeley, James
Peck, rally
Diem, linda
Keeley, James
Application Number:
JP2001533170A
Publication Date:
April 02, 2003
Filing Date:
October 27, 2000
Export Citation:
Assignee:
Kosan Biosciences, Inc.
International Classes:
C12N1/19; C12N1/21; C12N5/10; C12N9/90; C12N15/61; C12P11/00; C12P19/62; (IPC1-7): C12N1/21; C12N1/19; C12N5/10
Foreign References:
| WO1998027203A1 | 1998-06-25 |
Attorney, Agent or Firm:
Shusaku Yamamoto (2 outside)