【発明の名称】L―(―)―2―アミノ―3―(3,4―ジヒドロキシフェニル)プロパン酸の合成方法

Title:

【発明の名称】L―(―)―2―アミノ―3―(3,4―ジヒドロキシフェニル)プロパン酸の合成方法

Document Type and Number:

Japanese Patent JP2507069

Kind Code:

B2

Abstract:

New process for the synthesis of the levodopa, L-(-)-2-amino-3-(3,4-dihydroxyphenyl)propionic acid, drug used in the treatment of the Parkinson's disease. The process consists in resolving with d-camphorsulfonic acid, or with a salt thereof,the d,l-2-amino-3-(3,4-dimethoxyphenyl)propionitrile, obtained from the 3,4-dimethoxyphenylacetaldehyde, and in the subsequent hydrolysis and methylation, by means of concentrated solutions of haloid acids, of the d-2-amino-3-(3,4-dimethoxyphenyl)propionitrile and of salts thereof.

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Inventors:

BINSENTSUO KANNATA
GIANKARURO TAMERURANI
MAURO MOROTSUTEI

Application Number:

JP18015289A

Publication Date:

June 12, 1996

Filing Date:

July 12, 1989

Export Citation:

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Assignee:

ITARIAKOKU

International Classes:

C07C221/00; C07C227/34; C07C229/36; C07C227/26; C07C237/20; C07C255/26; C07C255/43; C07C309/19; (IPC1-7): C07C229/36; C07C227/26

Domestic Patent References:

JP56115749A
JP4920305B1

Other References:

【文献】イスラエル特許59048(IL,A)

Attorney, Agent or Firm:

Akira Asamura (3 outside)

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