Title:
【発明の名称】1α,24(S)-ジヒドロキシビタミンD▲下2▼の調製及び使用方法
Document Type and Number:
Japanese Patent JP3179495
Kind Code:
B2
Abstract:
1 alpha ,24(S)-Dihydroxy vitamin D2 which is useful as an active compound of pharmaceutical compositions for the treatment of disorders of calcium metabolism and for various skin disorders. The invention also includes preparation of synthetic 1 alpha ,24(S)-dihydroxy vitamin D2 starting from ergosterol which is converted in six steps to 24-hydroxyergosterol. 24-Hydroxyergosterol is irradiated and thermally converted to 24-hydroxy vitamin D2 which is converted in six steps to 1 alpha ,24(S)-dihydroxy vitamin D2. The syntheses also produced novel intermediates.
Inventors:
Bishop Charles W
Horst Ronald El
Jones Glenville
Kozewski Nicholas Jay
Natson Joyce Sea
Moriathie Robert M
Line Hard Timothy A
Pen master rage
Stragnell Stephen
Guolien
Singal Sanjay Kay
Zao Ray
Horst Ronald El
Jones Glenville
Kozewski Nicholas Jay
Natson Joyce Sea
Moriathie Robert M
Line Hard Timothy A
Pen master rage
Stragnell Stephen
Guolien
Singal Sanjay Kay
Zao Ray
Application Number:
JP50736194A
Publication Date:
June 25, 2001
Filing Date:
August 30, 1993
Export Citation:
Assignee:
Bone Care International, Inc.
International Classes:
A61K31/59; A61P3/02; A61P3/14; A61P17/00; A61P19/08; A61P35/00; A23K1/16; C07C401/00; C07J9/00; C07J71/00; (IPC1-7): C07C401/00; A23K1/16; A61K31/59; A61P17/00; A61P19/08; A61P35/00
Other References:
【文献】国際公開92/12165(WO,A1)
Attorney, Agent or Firm:
Minoru Nakamura (6 outside)