Title:
【発明の名称】血小板凝集抑制剤として有効な置換β-アミノ酸誘導体
Document Type and Number:
Japanese Patent JP2813462
Kind Code:
B2
Abstract:
Novel substituted beta amino acid derivatives having the general formula: are provided, in which eg. R<2> is selected from the group consisting of hydrogen, lower alkyl radicals, lower alkenyl radicals, lower alkynyl radicals, alicyclic hydrocarbon radicals, aromatic hydrocarbon radicals, wherein said radicals are optionally substituted with hydroixy, lower alkoxy, lower alkyl, halogen, nitro, cyano, azido, ureido, ureylene, carboxyl or carbonyl derivatives, trifluoromethyl, acyloxy, alkylthio, arylthio, alkylsulfenyl, arylsulfenyl, alkylsulfonyl, arylsulfonyl, amino, alkylamino, trialkylsilyl, aminosulfonyl, dialkylamino, alkanoylamino, aroylamino, phenyl, naphtyl, lower alkynyl which are optionally substituted with one or more of the following: halogen, nitro, lower alkoxy, lower alkyl, trialkylsilyl, azide and phenyl; the invention also pertains to pharmaceutical composition comprising such derivatives.
Inventors:
Bobby, Philip Roger
Rico, Joseph Gerais
Rogers, Thomas Edward
Tojoeng, Foushiong
Zablocchi, Jeffrey Alan
Rico, Joseph Gerais
Rogers, Thomas Edward
Tojoeng, Foushiong
Zablocchi, Jeffrey Alan
Application Number:
JP50771193A
Publication Date:
October 22, 1998
Filing Date:
October 06, 1992
Export Citation:
Assignee:
Monsanto Company
G.D.Searle & Company
G.D.Searle & Company
International Classes:
A61K31/215; A61P7/02; C07C257/18; C07C259/04; C07C259/06; C07C311/46; C07C317/50; A61K31/19; C07F7/08; C07F7/10; (IPC1-7): C07C257/18; C07F7/10; C07C317/50; C07C259/04; A61K31/215; A61K31/19
Domestic Patent References:
| JP4217652A | ||||
| JP7500335A |
Other References:
【文献】米国特許5344957(US,A)
【文献】国際公開93/18058(WO,A1)
【文献】国際公開93/18058(WO,A1)
Attorney, Agent or Firm:
Akira Asamura (3 outside)