Title:
【発明の名称】置換された四環式テトラヒドロフラン誘導体
Document Type and Number:
Japanese Patent JP3199751
Kind Code:
B2
Abstract:
PCT No. PCT/EP97/01829 Sec. 371 Date Oct. 6, 1998 Sec. 102(e) Date Oct. 6, 1998 PCT Filed Apr. 9, 1997 PCT Pub. No. WO97/38991 PCT Pub. Date Oct. 23, 1997This invention concerns the compounds of formula (I), the N-oxide forms, the pharmaceutically acceptable addition salts and the stereoisomeric forms thereof, wherein n is zero to 6; p and q are zero to 4; r is zero to 5; R1 and R2 each independently are hydrogen; optionally substituted C1-6alkyl; C1-6alkylcarbonyl; halomethylcarbonyl; or R1 and R2 taken together with the nitrogen atom to which they are attached may form a morpholinyl ring or an optionally substituted heterocycle; each R3 and R4 independently are halo, cyano, hydroxy, halomethyl, halomethoxy, carboxyl, nitro, amino, mono- or di(C1-6alkyl)amino, C1-6alkylcarbonylamino, aminosulfonyl, mono- or di(C1-6alkyl)aminosulfonyl, C1-6alkyl, C1-6alkyloxy, C1-6alkylcarbonyl, C1-6alkyloxycarbonyl; each R5 independently is C1-6alkyl, cyano or halomethyl; X is CR6R7, NR8, O, S, S(=O) or S(=O)2; aryl is optionally substituted phenyl; provided that the compound is other than (+/-)-3,3a,8,12b-tetrahydro-N-methyl-2H-dibenzo[3,4:6,7]-cyclohepta[1,2-b]-furan-2-methanamine oxalic acid. The compounds of formula (I) may be used as therapeutic agents in the treatment or the prevention of CNS disorders, cardiovascular disorders or gastrointestinal disorders.
Inventors:
Jill-Lopetegui, Pillar
Fernandez-Gadea, Francisco Xavier
Mailt, Theo Franz
Fernandez-Gadea, Francisco Xavier
Mailt, Theo Franz
Application Number:
JP53673397A
Publication Date:
August 20, 2001
Filing Date:
April 09, 1997
Export Citation:
Assignee:
JANSSEN PHARMACEUTICA NAAMLOZE VENNOOTSCHAP
International Classes:
A61K31/00; A61K31/34; A61K31/343; A61K31/4025; A61K31/4035; A61K31/443; A61K31/445; A61K31/4465; A61K31/4523; A61K31/4525; A61K31/495; A61K31/496; A61K31/535; A61K31/5375; A61K31/5377; A61K31/55; A61P1/00; A61P1/14; A61P9/00; A61P9/02; A61P25/06; A61P25/18; A61P25/22; A61P25/24; A61P25/30; C07D307/93; C07D405/02; C07D405/06; C07D491/048; C07D493/04; C07D493/10; C07D495/04; (IPC1-7): C07D307/93; A61K31/343; A61K31/4025; A61K31/4035; A61K31/55; A61P25/06; A61P25/18; A61P25/22; A61P25/24; A61P25/30; C07D405/06; C07D493/04
Attorney, Agent or Firm:
Heiyoshi Odashima (1 person outside)