Title:
【発明の名称】トロンビン阻害剤
Document Type and Number:
Japanese Patent JP3486412
Kind Code:
B2
Abstract:
4-substituted cyclohexylamine derivatives which are thrombin catalytic site inhibitors and which are useful as anticoagulants. These compounds show selectivity for thrombin over other trypsin-like enzymes and have oral bioavailability. They have formula (a) or (b), for example (c).
Inventors:
Bever, daniel f
Lewis, S-Doll
Siheaur, The Youth A
Fuen, Don-May
Natsuto, Ruth Ef
Bladay, Stephen F
Lewis, S-Doll
Siheaur, The Youth A
Fuen, Don-May
Natsuto, Ruth Ef
Bladay, Stephen F
Application Number:
JP52446394A
Publication Date:
January 13, 2004
Filing Date:
April 25, 1994
Export Citation:
Assignee:
Merck End Company, Inc.
International Classes:
A61K31/16; A61K31/19; A61K31/215; C07D211/36; A61K31/40; A61K31/445; A61K38/00; A61P7/02; A61P43/00; C07C237/10; C07C271/22; C07D207/16; C07D211/60; C07K5/02; C07K5/06; C07K5/065; C07K5/087; (IPC1-7): C07K5/087; A61K38/00; A61P7/02
Domestic Patent References:
| JP572253A | ||||
| JP5504775A |
Attorney, Agent or Firm:
Yoshio Kawaguchi (2 outside)