Title:
【発明の名称】トリ‐アザ大環状化合物及びそれらの金属錯体
Document Type and Number:
Japanese Patent JP2683080
Kind Code:
B2
Abstract:
Ti-aza macrocycles of formula (1), wherein m and n, which may be the same or different, is each zero or an integer 1, 2, or 3; p is zero or an integer 1 or 2; q is zero or an integer from 1 to 6 inclusive; R1, R2 and R3, which may be the same or different, is each a hydrogen atom or an alkyl, alkoxyalkyl, -CO2H, -SO3H, PO3H2 or aryl group; L is a covalent bond or linker group; Z is a hydrogen atom or a reactive functional group, with the proviso that when L is a covalent bond Z is a reactive functional group; and metal complexes and/or salts thereof are described together with processes for their preparation and compositions containing them. The compounds are useful for imaging and in the treatment of abnormal cell disorders, such as in the treatment of tumours, and are particularly suitable for coupling to other molecules such as proteins for use in diagnosis and therapy.
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Inventors:
Hoodie, david
Millikan, Thomas Andrew
Millikan, Thomas Andrew
Application Number:
JP50668788A
Publication Date:
November 26, 1997
Filing Date:
August 12, 1988
Export Citation:
Assignee:
Cell Tech Therapeutics Limited
International Classes:
A61K31/395; A61K39/395; A61K47/22; A61K47/24; C07H17/02; A61K47/48; A61K49/00; A61P35/00; C07D255/02; C07D401/06; C07F9/6515; (IPC1-7): C07D255/02; A61K39/395; A61K49/00; C07D401/06
Domestic Patent References:
| JP62501070A |
Attorney, Agent or Firm:
Aoki Akira (4 outside)