Title:
【発明の名称】クロストリジウム・ディフィシル疾患の治療及び予防のためのワクチン及び抗トキシン
Document Type and Number:
Japanese Patent JP2002514886
Kind Code:
A
Abstract:
The present invention provides neutralizing antitoxin directed against C.difficile toxins. These antitoxins are produced in avian species using soluble recombinant C.difficile toxin proteins. The avian antitoxins are designed so as to be orally administrable in therapeutic amounts and may be in any form (i.e., as a solid or in aqueous solution). Solid forms of the antitoxin may comprise an enteric coating. These antitoxins are useful in the treatment of humans and other animals intoxicated with at least one bacterial toxin. The invention further provides vaccines capable of protecting a vaccinated recipient from the morbidity and mortality associated with C.difficile infection. These vaccines are useful for administration to humans and other animals at risk of exposure to C.difficile toxins.
Inventors:
Williams, James, A.
Pad high, nisha, buoy.
Kink, John, A.
Sally, Bruce, S.
Stafford, Douglas, Sea.
Filka, Joseph, Earl.
Pad high, nisha, buoy.
Kink, John, A.
Sally, Bruce, S.
Stafford, Douglas, Sea.
Filka, Joseph, Earl.
Application Number:
JP51412796A
Publication Date:
May 21, 2002
Filing Date:
October 23, 1995
Export Citation:
Assignee:
Promega Corporation
International Classes:
C12N15/09; A61K9/28; A61K38/00; A61K39/08; A61K39/395; A61K39/40; A61K47/10; A61P31/04; C07K1/16; C07K1/22; C07K14/245; C07K14/33; C07K14/38; C07K16/00; C07K16/02; C07K16/06; C07K16/12; C07K16/18; C07K17/08; C07K19/00; C12N1/20; C12N1/21; C12N15/00; C12N15/13; C12N15/31; C12P21/08; G01N33/53; G01N33/543; G01N33/546; G01N33/569; A61K39/00; C12N; (IPC1-7): C12N15/09; A61K39/08; A61K39/395; A61P31/04; C07K14/33; C07K16/12; C07K19/00; C12N1/21; C12P21/08; G01N33/53; G01N33/569
Attorney, Agent or Firm:
Yusuke Hiraki (2 outside)