Title:
【発明の名称】Xa因子の阻害剤としてのアルケニルおよびアルキニル化合物
Document Type and Number:
Japanese Patent JP2003522733
Kind Code:
A
Abstract:
Alkenyl and alkynyl compounds as potent and highly selective inhibitors of factor Xa isolated or assembled in the prothrombinase complex and compositions containing such alkenyl and alkynyl compounds are described. Such compounds show selectivity for factor Xa over other proteases of the coagulation (e.g., thrombin, fvIIa, flXa) or the fibrinolytic cascades (e.g., plasminogen activators, plasmin). Methods for using such alkenyl and alkynyl compounds as diagnostic or therapeutic agents for prevention or treatment of a condition in a mammal characterized by undesired coagulation disorders, such as thrombosis, are also described.
Inventors:
Song, Yong Hong
Scarborough, Robert, M.
Two, Bin-Yang
Scarborough, Robert, M.
Two, Bin-Yang
Application Number:
JP2000598474A
Publication Date:
July 29, 2003
Filing Date:
February 11, 2000
Export Citation:
Assignee:
Core Therapeutics, Incorporated
International Classes:
C07D295/14; A61K31/18; A61K31/192; A61K31/195; A61K31/216; A61K31/341; A61K31/40; A61K31/41; A61K31/415; A61K31/4174; A61K31/44; A61K31/4409; A61K31/472; A61K31/4725; A61K31/495; A61K31/505; A61K31/517; A61P7/00; A61P7/02; A61P7/04; A61P9/00; A61P9/10; A61P11/00; A61P31/04; A61P43/00; C07C257/18; C07C311/29; C07C311/46; C07C311/51; C07D213/56; C07D213/58; C07D213/70; C07D213/74; C07D213/75; C07D217/22; C07D231/12; C07D233/61; C07D239/42; C07D239/94; C07D257/04; C07D295/16; C07D307/54; C07D401/12; C07D521/00; (IPC1-7): C07C311/29; A61K31/18; A61K31/192; A61K31/216; A61K31/40; A61K31/41; A61K31/4174; A61K31/44; A61K31/4409; A61K31/495; A61K31/505; A61P7/02; A61P9/00; A61P9/10; A61P11/00; A61P31/04; C07D213/58; C07D213/74; C07D233/61; C07D239/42; C07D257/04; C07D295/14; C07D295/16
Attorney, Agent or Firm:
Yuichi Yamada (1 person outside)