Title:
【発明の名称】変容免疫学的特性、性能および/またはレセプター特異性を有する糖タンパク質ホルモンの類似体
Document Type and Number:
Japanese Patent JP3330373
Kind Code:
B2
Abstract:
The invention relates to modified chorionic gonadotropin (CG) alpha, beta-heterodimeric polypeptides comprising a glycoprotein hormone alpha-subunit polypeptide and a non-naturally occurring beta-subunit polypeptide. The modifications in the beta-subunit polypeptide involve the deletion, addition, or substitution of one or more amino acid residues. The modified heterodimeric polypeptides of the invention have different properties compared to native hCG. Certain alpha, beta-heterodimeric polypeptides bind to LH and FSH receptors and stimulate steroidogenesis in testicular and ovarian cells. Other alpha, beta-heterodimeric polypeptides bind to LH receptors but have lower efficacy than hCG to stimulate steroidogenesis in testicular and ovarian cells.
Inventors:
Campbell, Robert Kay
Moyle, William Earl
Moyle, William Earl
Application Number:
JP51017991A
Publication Date:
September 30, 2002
Filing Date:
May 07, 1991
Export Citation:
Assignee:
University of Medicine and Dentistry of New Jersey
International Classes:
A61K38/22; A61K38/24; A61P15/00; C07K14/145; C07K14/575; C07K14/59; C07K16/26; C07K19/00; C12N15/09; C12N15/16; C12N15/85; C12N15/89; C12P21/02; A61K38/00; A61K39/00; C12R1/19; C12R1/91; (IPC1-7): C07K14/59; C07K19/00
Attorney, Agent or Firm:
Haruo Hamada