Title:
【発明の名称】スーパーオキシドをジスムテートする触媒として有効な窒素含有大環状リガンドのマンガン錯体の生体分子結合体
Document Type and Number:
Japanese Patent JP2000513322
Kind Code:
A
Abstract:
Bioconjugates of low molecular weight mimics of superoxide dismutase (SOD) represented by formula (I), wherein R, R', R1, R'1, R2, R'2, R3, R'3, R4, R'4, R5, R'5, R6, R'6, R7, R'7, R8, R'8, R9, R'9, X, Y, Z and n are as defined herein, useful as therapeutic agents for inflammatory disease states and disorders, such as ischemic/reperfusion injury, stroke, atherosclerosis, and all other conditions of oxidant-induced tissue damage or injury.
Inventors:
Newman, William, Elle
Relay, dennis, pee
Wais, randy, h
Henke, Susan, El
Lennon, patrick, jay
Aston, Carl, W
Relay, dennis, pee
Wais, randy, h
Henke, Susan, El
Lennon, patrick, jay
Aston, Carl, W
Application Number:
JP50933697A
Publication Date:
October 10, 2000
Filing Date:
August 14, 1996
Export Citation:
Assignee:
Monsanto Company
International Classes:
A61K47/48; A61K49/06; C07D259/00; C07F13/00; (IPC1-7): C07D259/00; A61K31/00; A61K47/48
Attorney, Agent or Firm:
Akira Asamura (3 outside)