【発明の名称】足場としてモジュラー性PKS遺伝子クラスターを使用して生成されるコンビナトリアルなポリケチドライブラリー

Title:

【発明の名称】足場としてモジュラー性PKS遺伝子クラスターを使用して生成されるコンビナトリアルなポリケチドライブラリー

Document Type and Number:

Japanese Patent JP2001524829

Kind Code:

A

Abstract:

Combinatorial libraries of polyketides can be obtained by suitable manipulation of a host modular polyketide synthase gene cluster such as that which encodes the PKS for erythromycin. The combinatorial library is useful as a source of pharmaceutically active compounds. In addition, novel polyketides and antibiotics are prepared using this method.

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Inventors:

Coura, Kaitan
Ashley, Gary
Huh, Hong
Khao, Camilla M.
Robert McDaniel

Application Number:

JP54741398A

Publication Date:

December 04, 2001

Filing Date:

April 30, 1998

Export Citation:

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Assignee:

Kosan Biosciences, Inc.
Board of Trustees of the Leland Stanford Junior University

International Classes:

A61K31/335; A61K31/351; A61K31/7048; A61P31/04; C07D309/10; C07D309/30; C07D309/32; C07D313/00; C07D313/18; C07D323/00; C07D493/10; C07H17/04; C07H17/08; C12M1/00; C12N1/21; C12N15/52; C12N15/09; C12P17/06; C07B61/00; (IPC1-7): C12N15/09; A61K31/335; A61K31/351; A61K31/7048; A61P31/04; C07D309/10; C07D309/30; C07D309/32; C07D313/00; C07D313/18; C07D493/10; C07H17/04; C07H17/08; C12M1/00; C12N1/21; C12P17/06

Attorney, Agent or Firm:

Shusaku Yamamoto

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