Title:
【発明の名称】リガンド依存性核内受容体とコアクチベーターの相互作用を検出するための組成物および方法
Document Type and Number:
Japanese Patent JP2002510051
Kind Code:
A
Abstract:
The invention provides methods for identifying agents that are ligands for nuclear receptors. The methods include conducting multiplexed assays utilizing positive hybrid systems, reverse hybrid systems, direct interaction assays and other assays to screen for ligands having activity with a receptor of interest. The methods can be performed in various multiplexing formats to produce a profile that can be used to categorize a test ligand relative to known agonists and antagonists.
Inventors:
Northrop, Jeffrey Paul
Heart, Charles Praray
Shertz, Peter Joseph
Heart, Charles Praray
Shertz, Peter Joseph
Application Number:
JP2000541522A
Publication Date:
April 02, 2002
Filing Date:
April 01, 1999
Export Citation:
Assignee:
GLAXO GROUP LIMITED
International Classes:
G01N33/53; A61K45/00; C07K2/00; C07K4/00; C07K7/06; C07K7/08; C07K14/47; C12N1/15; C12N1/19; C12N5/00; C12N15/09; C12N15/10; C12Q1/02; C40B20/04; C40B30/00; C40B40/02; C40B50/06; G01N33/15; G01N33/50; G01N33/58; G01N33/68; (IPC1-7): G01N33/53; C07K2/00; C07K4/00; C07K14/47; C12N1/15; C12N1/19; C12N5/00; C12N15/09; C12Q1/02; G01N33/15; G01N33/50
Attorney, Agent or Firm:
Takehiko Suzue (4 outside)