Title:
【発明の名称】RNAの5 ́キャップ構造の修飾によりRNA活性を変調させるための組成物および方法
Document Type and Number:
Japanese Patent JPH06500075
Kind Code:
A
Abstract:
Methods for achieving therapeutic treatment of diseases and for regulating gene expression in biological experimental systems via modification or removal of the 5' Cap structure of targeted ribonucleic acids are disclosed. Modification or removal of the 5' Cap structure is achieved in accordance with preferred embodiments utilizing antisense compounds which are complementary to the 5' terminus of the targeted RNA and have attached to them reactive moieties explicitly designed for chemical modification of or cleavage reactions with the 5' Cap structure of RNA.
Inventors:
Baker, Brenda F
Application Number:
JP51119891A
Publication Date:
January 06, 1994
Filing Date:
May 22, 1991
Export Citation:
Assignee:
Isis PharmaceuticalsInc
International Classes:
A61K31/7135; A61P31/12; C07H21/00; C07H21/02; A61K31/70; C07H23/00; C12N15/09; C12Q1/68; A61K; (IPC1-7): C07H21/02; A61K31/70; C07H23/00; C12N15/11; C12Q1/68
Attorney, Agent or Firm:
Kyozo Yuasa (5 people outside)