Title:
【発明の名称】交感神経性持続性痛みの治療のための組成物および方法
Document Type and Number:
Japanese Patent JP2786538
Kind Code:
B2
Abstract:
Method of diagnosing and treatment of sympathetically maintained pain. Sympathetically maintained pain is diagnosed and treated using the method of injecting or transdermally applying an alpha -adrenergic blocking agent selected from the group consisting of alpha -adrenergic antagonist, alpha -1-adrenergic antagonist, alpha 2 adrenergic agonist, or other drug that depletes sympathetic norepineprhine. Sympathetic efferent fibers release norepinephrine which in turn activates alpha -adrenergic receptors. Activation of these receptors, either directly or indirectly, excites nociceptors. Activity in the nociceptors then evokes pain, and causes further discharge of nociceptors. Intravenous administration of phentolamine blocks the activation of alpha -adrenergic receptors which causes the pain to be relieved. The use of a clonidine, another alpha -adrenergic blocking agent, in a patch similarly achieved substantive pain reduction.
Inventors:
KYANBERU JEIMUZU ENU
Application Number:
JP50606991A
Publication Date:
August 13, 1998
Filing Date:
February 26, 1991
Export Citation:
Assignee:
EI AARU SHII 1 INC
International Classes:
A61K31/135; A61K31/14; A61K31/155; A61K31/395; A61K31/415; A61K31/47; A61K31/475; A61K31/505; A61K45/00; A61P25/04; (IPC1-7): A61K45/00; A61K31/135; A61K31/14; A61K31/395; A61K31/415; A61K31/47; A61K31/505
Domestic Patent References:
| JPH01216928A |
Attorney, Agent or Firm:
Shusaku Yamamoto