【発明の名称】インターフェロンガンマの副因子機能およびその受容体

Japanese Patent JPH09502965

A

This invention relates (a) to a 540 kb YAC which encodes the necessary species-specific factor(s) and is able to substitute for human Chromosome 21 to reconstitute the Hu-IFN-gamma receptor-mediated induction of class I HLA antigens; (b) to the construction of a plasmid to integrate the selective marker for antibiotic G418 resistance into YACs and to delete some of the human DNA fragments from YACs in order to facilitate the manipulation of human genomic DNA in yeast artificial chromosome (YAC) clones; (c) to two fragmentation vectors, pSE1 and pSE2, which contain a neomycin resistance and URA3 gene, developed for targeting yeast artificial chromosomes (YACs) containing human genomic DNA; (d) to a chromosomal fragmentation procedure employed to produce a deletion set of yeast artificial chromosomes (YACs) from a parental YAC (GART D142H8) known to map to Chromosome 21q and to encode the human interferon-gamma receptor (Hu-IFN-gamma R) accessory factor gene as well as the phosphoribosylglycinamide formyltranisferase (GART) gene; and (e) to the isolation of cDNA clones that encode the necessary species-specific factor and that are able to substitute for human Chromosome 21 to reconstitute the Hu-IFN-gamma receptor-mediated induction of class I HLA antigens.

Pestka, Sydney
Kotenko, Sergey
Saw, gemog
Donnelly, Robert Jay
Mariano, Thomas M
Cook, Jeffrey Earl
Emmanuel, Stuart
Schwartz, Barbara

JP50770395A

March 25, 1997

August 22, 1994

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University of Medicine and Dentistry of New Jersey

C12N15/09; A61K38/00; A61K39/395; A61K48/00; A61K49/00; A61P31/12; A61P35/00; C07H21/04; C07K14/57; C07K14/705; C07K14/715; C12N1/21; (IPC1-7): A61K38/00; A61K48/00; A61K49/00; C07H21/04; C07K14/57

Haruo Hamada (1 person outside)

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