【発明の名称】NADE(P75NTR関連細胞死実行物質)をコードする遺伝子及びその使用 - THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK

Title:

【発明の名称】NADE(P75NTR関連細胞死実行物質)をコードする遺伝子及びその使用

Document Type and Number:

Japanese Patent JP2003501079

Kind Code:

A

Abstract:

This invention provides an isolated nucleic molecule encoding a polypeptide capable of binding a p75^NTRreceptor, and a purified version of said polypeptide capable of binding a p75^NTRreceptor. This invention provides a method of producing a purified polypeptide capable of binding a p75^NTRreceptor. This invention provides an antisense oligonucleotide having a nucleic acid sequence capable of specifically hybridizing to an mRNA molecule encoding the above described polypeptide. This invention provides a method producing a polypeptide capable of binding p75^NTrecptor into a suitable vector. This invention provides a method of inducing apoptosis, a method of determining physiological effects, a method for identifying an apoptosis inducing or inhibiting compound, a method for screening cDNA libraries of said polypeptide, a method to induce caspase-2 and caspase-3 activity to cleave poly (ADP-ribose) polymerase and fragment nuclear DNA in a cell, a method to inhibit NF-kappaB activation in a cell, a method to detect a neurodegenerative disease, a method of producing the isolated human HGR74 protein into a suitable vector, a pharmaceutical composition comprising a purified polypeptide capable of binding a p75^NTRreceptor and a pharmaceutically acceptable carrier and a method of identifying a compound which is an apoptosis inhibitor.

More Like This:

JP2008501632	Galanin receptor and brain damage
JP4750718	Protein with a short-chain peptide consisting of acidic amino acids added
WO/2001/020037	PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA AND DISORDERS OF LIPID METABOLISM

Inventors:

Takaaki Sato

Application Number:

JP2001502545A

Publication Date:

January 14, 2003

Filing Date:

June 07, 2000

Export Citation:

Click for automatic bibliography generation Help

Assignee:

THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK

International Classes:

A61K38/00; A61P43/00; C07K14/47; C07K14/475; C07K16/18; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/02; C12N15/09; C12P21/02; C12P21/08; C12Q1/02; C12Q1/68; G01N33/15; G01N33/50; G01N33/566; G01N33/68; A01K67/027; (IPC1-7): C12N15/09; A01K67/027; A61K38/00; A61P43/00; C07K14/47; C07K16/18; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/02; C12P21/02; C12Q1/02; C12Q1/68; G01N33/15; G01N33/50; G01N33/566; G01N33/68

Attorney, Agent or Firm:

Takehiko Suzue (4 outside)

Previous Patent: JP2003501078

Next Patent: ヒトおよび動物に使用される細菌株、加工された植物抽出物およびプロバ�...