Title:
【発明の名称】カリウムチャネル変調物質としてのシクロブテン―3,4―ジオンの複素環式メチルアミノ誘導体
Document Type and Number:
Japanese Patent JP2000512655
Kind Code:
A
Abstract:
The compounds of formula (I) wherein R1 and R2 are, independently, hydrogen, straight chain alkyl, branched chain alkyl, cycloalkyl, bicycloalkyl or aralkyl, wherein the aromatic moiety of the aralkyl group may be optionally substituted with one to three straight chain alkyl, halogen, nitro, cyano, alkoxy, alkoxycarbonyl, trifluoromethyl or trifluoromethoxy groups; R3 is hydrogen, formyl, alkanoyl, alkenoyl, alkylsulfonyl, aroyl, arylalkenoyl, arylsulfonyl, arylalkanoyl or arylalkylsulfonyl; A is selected from the group consisting of (a), (b), (c), (d) and (e) wherein n is 0 or 1; R4, R5 and R6 are, independently, cyano, nitro, amino, alkyl, perfluoroalkyl, alkoxy, perfluoroalkoxy, alkylamino, dialkylamino, sulfamyl, alkylsulfonamido, arylsulfonamido, alkylcarboxamido, arylcarboxamido, alkanoyl, alkylsulfonyl, perfluoroalkylsulfonyl, arylsulfonyl, chloro, bromo, fluoro, iodo, 1-imidazolyl, carboxyl or hydrogen; or a pharmaceutically acceptable salt thereof, relax smooth muscles.
Inventors:
Herbst, David Richard
Battera, John Anthony
Gracefa, Russell Francis
Battera, John Anthony
Gracefa, Russell Francis
Application Number:
JP50305198A
Publication Date:
September 26, 2000
Filing Date:
June 10, 1997
Export Citation:
Assignee:
American Home Products Corporation
International Classes:
A61K31/00; A61K31/34; A61K31/343; A61K31/44; A61K31/4402; A61K31/4406; A61K31/4409; A61K31/505; A61P1/00; A61P1/12; A61P13/00; A61P13/10; C07D239/26; A61P43/00; C07D213/36; C07D213/38; C07D307/81; C07D307/82; (IPC1-7): C07D213/36; A61P1/12; A61P13/10; A61P43/00; A61K31/343; A61K31/4402; A61K31/4406; A61K31/4409; A61K31/505; C07D239/26; C07D307/81; C07D307/82
Attorney, Agent or Firm:
Aoyama Ryo (1 person outside)