Title:
【発明の名称】タバコ及びその燃焼副産物中の高次糖付加最終生成物の存在を基にする測定方法及び治療方法
Document Type and Number:
Japanese Patent JP2000507346
Kind Code:
A
Abstract:
Methods are disclosed for measuring the accumulation of advanced glycosylation endproducts (AGEs), and for lowering the accumulation of advanced glycosylation endproducts, which are predicated on the discovery that such AGEs and their precedent glycotoxins are present in tobacco and its byproducts. More particularly the methods focus on the observation that individuals who smoke or otherwise use tobacco have increased levels of AGEs relative to non-smoking individuals. The present methods relate to the measurement of AGE levels in both individuals and in tobacco and its byproduct, smoke, and to the treatment of such individuals with agents capable of reacting with glycosylation products to either avert or diminish the accretion of AGEs in the body. Methods are also disclosed for the evaluation of the tobacco products to determine their storage status and organoleptic capacity and potential, for the treatment of the ambient atmosphere to lower AGE levels, and for the treatment of the tobacco products and combustion byproducts to lower AGE levels therein. For example, air or other samples may be taken and evaluated by a dosimeter or like device, to determine whether AGE levels exceed normal, after which measures could be implemented to remediate the ambient condition. Likewise, filters and similar devices for removing AGEs from tobacco smoke are disclosed. All such methods and corresponding materials are contemplated and included.
Inventors:
Ceramy Antony
Bucara Richard Jay
Vlassala Helen
Fons Henry W
Cerami Clara Jay
Bucara Richard Jay
Vlassala Helen
Fons Henry W
Cerami Clara Jay
Application Number:
JP52384697A
Publication Date:
June 13, 2000
Filing Date:
December 23, 1996
Export Citation:
Assignee:
The Picower Institute For Medical Research
Alteon Incorporated
Alteon Incorporated
International Classes:
A24D3/06; A24B15/36; A24D3/14; A61K31/00; A61K31/425; A61K31/426; A61P9/00; A61P9/10; C07D277/20; C07K14/415; C07K16/16; G01N33/53; G01N33/543; G01N33/68; (IPC1-7): G01N33/53; A24D3/06; A61K31/426; A61P9/10
Attorney, Agent or Firm:
Minoru Nakamura (7 outside)