Title:
【発明の名称】選択的エストロゲン受容体モジュレーターと性ステロイド前駆体の組合せの医学的使用
Document Type and Number:
Japanese Patent JP2002517433
Kind Code:
A
Abstract:
Novel methods for the medical treatment and/or inhibition of the development of breast cancer, hypercholesterolemia, hyperlipidemia or atherosclerosis in susceptible warm-blooded animals including humans involving administration of selective estrogen receptor modulator and an amount of a sex steroid precursor selected from the group consisting of dehydroepiandrosterone, dehydroepiandrosterone sulfate, androst-5-ene-3ß,17ß-diol, and compounds converted in vivo to one of the foregoing precursors.
Further administration of bisphosphonates in combination with selective estrogen receptor modulators and/or sex steroid precursors is disclosed. Pharmaceutical compositions for delivery of active ingredients and kits useful to the invention are disclosed.
Inventors:
Fernando Lovely
Application Number:
JP2000553043A
Publication Date:
June 18, 2002
Filing Date:
June 10, 1999
Export Citation:
Assignee:
ENDORECHERCHE, INC.
International Classes:
A61K31/133; A61K31/381; A61K31/40; A61K31/4025; A61K31/403; A61K31/404; A61K31/4436; A61K31/4453; A61K31/453; A61K31/475; A61K31/56; A61K31/565; A61K31/568; A61K31/5685; A61K31/57; A61K31/66; A61K45/00; A61K45/06; A61P3/06; A61P9/10; A61P15/00; A61P15/02; A61P19/10; A61P21/00; A61P35/00; C07D209/10; C07D311/60; C07D333/56; (IPC1-7): A61K45/00; A61K31/133; A61K31/381; A61K31/40; A61K31/4025; A61K31/404; A61K31/4436; A61K31/4453; A61K31/453; A61K31/475; A61K31/568; A61K31/5685; A61P3/06; A61P9/10; A61P15/00; A61P19/10; A61P35/00
Domestic Patent References:
| JPH08505629A | 1996-06-18 | |||
| JPH11500133A | 1999-01-06 | |||
| JPH10147522A | 1998-06-02 | |||
| JPH1036347A | 1998-02-10 | |||
| JPH10511961A | 1998-11-17 | |||
| JP2000505444A | 2000-05-09 |
Foreign References:
| WO1996026201A1 | 1996-08-29 | |||
| WO1996021443A1 | 1996-07-18 |
Attorney, Agent or Firm:
Aoyama Ryo (2 outside people)