Title:
【発明の名称】可溶性放射性有毒物質の酵素変換による、癌治療のための方法および組成物
Document Type and Number:
Japanese Patent JP2001524941
Kind Code:
A
Abstract:
A method for the treatment of cancer is disclosed which is capable of directing supra-lethal doses of radiation, called Hot-Spots, virtually exclusively to the cancer. The present invention involves a multi-step therapy process and includes a class of novel chemical agents. In accordance with the present invention, it was discovered that soluble precipitable materials can be made to accumulate as non-digestible precipitates in targeted cells as a result of enzyme action within the targeted cells. Accumulation is achieved by administering to the living host a soluble binary reagent made by attaching a targeting agent to a novel chemical agent which is a soluble precipitable material. The binary reagent binds to antigenic receptors on targeted cells which endocytose the binary reagent and transport it into the lysosomes where enzymes detach the soluble precipitable material from the targeting agent, causing it to precipitate, accumulate, and be retained in the cells. Increasing amounts of precipitate can be made to accumulate in cells by continuing the administration of the binary reagent. The accumulated precipitate is relocated to the extra-cellular fluid by selectively killing a fraction of cancer cells. Now relocated in the extra-cellular fluid of the cancer, the precipitate is used as a "platform" from which to generate Hot-Spots. A bispecific reagent with a non-mammalian enzyme moiety is made to bind to the precipitate. A soluble radioactive material is administered which is converted by the enzyme moiety of the bound bispecific reagent into a new form which is retained adjacent to the precipitate for an extended period of time, thereby generating Hot-Spots which non-selectively kill all cells adjacent to the precipitate in the extra-cellular fluid of the cancer.
Inventors:
Samuel Rose
Application Number:
JP53119198A
Publication Date:
December 04, 2001
Filing Date:
January 13, 1998
Export Citation:
Assignee:
Samuel Rose
International Classes:
A61K31/717; A61K31/722; A61K31/74; A61K38/00; A61K49/00; A61K51/04; A61P35/00; C07K16/00; A61K45/00; (IPC1-7): A61K45/00; A61K31/717; A61K31/722; A61K31/74; A61K38/00; A61K49/00; A61P35/00; C07K16/00
Attorney, Agent or Firm:
Kazuo Shamoto (5 outside)