Title:
【発明の名称】癌の処置のための方法および組成物
Document Type and Number:
Japanese Patent JP2002541200
Kind Code:
A
Abstract:
We have discovered that the administration of a G1 and/or S phase drug such as beta-lapachone in combination with a G2/M drug such as a taxane derivative such as paclitaxel resulted in a unexpected greater than additive (i.e., synergistic) reduction in the number of tumors (and tumor volume) as compared with the administration of these agents alone. In addition, no signs of toxicity or weight loss were observed. The present invention relates to a method for treating a mammalian tumor using combinations such as a taxane derivative, preferably paclitaxel, and a beta-lapachone, or a derivative or analog thereof.
More Like This:
| JP5414192 | Circadian rhythm adjusting composition |
| JP2018109067 | PHOTOCHROMIC COMPOUNDS |
Inventors:
Purdy, Arthur Bee.
Lee, Chang Jay.
Lee, You-Chi
Lee, Chang Jay.
Lee, You-Chi
Application Number:
JP2000610475A
Publication Date:
December 03, 2002
Filing Date:
April 14, 2000
Export Citation:
Assignee:
Dana-Farber Cancer Institute, Incorporated
International Classes:
C07D311/92; A61K31/122; A61K31/337; A61K31/35; A61K31/352; A61K31/4184; A61K31/427; A61K31/437; A61K31/704; A61K31/7042; A61K38/00; A61K45/00; A61K45/06; A61P35/00; (IPC1-7): A61K45/00; A61K31/337; A61K31/352; A61K31/4184; A61K31/427; A61K31/437; A61K31/704; A61K31/7042; A61K38/00; A61P35/00
Attorney, Agent or Firm:
Shusaku Yamamoto