Title:
【発明の名称】不所望細胞または組織を破壊しもしくはその成長を阻害する方法
Document Type and Number:
Japanese Patent JPH08505361
Kind Code:
A
Abstract:
This invention is a process for the use of a combination of ionizing radiation in conjunction with certain benzoporphyrin derivative compounds (BPD), preferably the compound benzoporphyrin derivative-monoacid ring-A (BPD-MA), to mediate the destruction of diseased or unwanted cells or tissues. Specifically, the invention is a method in which the sensitizer compounds are administered either systemically or locally to the diseased or unwanted tissue and irradiated with ionizing radiation (such as might be produced by a 60Co or x-ray source). The treatment with benzoporphyrin derivative compounds appears to sensitize the target cells or tissues in that those cells do not readily recover from irradiation exposure. In addition, the process may be used to lower the effective amount of radiation applied to a particular tissue target.
Inventors:
Richter, Anna
Levi, Julia Gee
Dolphin, David
Levi, Julia Gee
Dolphin, David
Application Number:
JP50571194A
Publication Date:
June 11, 1996
Filing Date:
August 17, 1993
Export Citation:
Assignee:
Quadra Logic Technologies, Inc.
International Classes:
A61K31/40; A61K31/409; A61K41/00; A61N5/10; A61P35/00; A61P43/00; (IPC1-7): A61K31/40; A61K31/40
Attorney, Agent or Firm:
Kyozo Yuasa (6 people outside)