Title:
【発明の名称】変更したNDPK機能を決定する方法及び嚢胞性線維症の診断法(diagnosis)
Document Type and Number:
Japanese Patent JP2002537793
Kind Code:
A
Abstract:
A peptide of relative molecular mass less than 6500 comprising at least ten consecutive amino acid residues surrounding the phenylalanine (508), or at least ten consecutive residues including a portion of the region between residues (508 and 551), in the polypeptide sequence of human cystic fibrosis transmembrane regulator (CFTR), or a variant or precursor thereof. A peptide as defined above having between 12 and 50 amino acid residues. Methods of treating cystic fibrosis are also disclosed. A method of classifying a disease state associated with epithelial cell dysfunction in a patient is disclosed. The method includes obtaining a suitable epithelial cell sample from the patient and determining for one or more of the following whether the measured parameter is altered compared to a control epithelial cell, the measured parameters being: (i) nucleoside diphosphate kinase (NDPK) function, (ii) phosphorylation of annexin, (iii) phosphorylation of other membrane proteins, and (iv) ATPase activity.
Inventors:
Muimo, richmond
Meter, anil
Meter, anil
Application Number:
JP2000602629A
Publication Date:
November 12, 2002
Filing Date:
March 02, 2000
Export Citation:
Assignee:
The University of Dundee
International Classes:
C07K14/47; C07K16/28; C12Q1/48; G01N33/50; A61K38/00; (IPC1-7): C12Q1/48; A61K38/00; A61K45/00; A61P11/00; A61P11/10; C07K14/47; C07K16/44; G01N33/15; G01N33/50
Attorney, Agent or Firm:
Hiroshi Arafune (1 person outside)