Title:
【発明の名称】第二アミドのα-メチレン炭素原子をヨウ素化または臭素化する方法
Document Type and Number:
Japanese Patent JPH0649674
Kind Code:
B2
Abstract:
A novel, facile, and specific process for alpha -iodinating or alpha -brominating the alpha -methylenic carbon of a straight chain, branched chain, or cyclic secondary amide, such as a lactam or an azasteroid, comprises reacting the amide with trialkylsilyl-X (R3Si-X), where X is Br, I, or Cl, and R is methyl, ethyl, or n-propyl, in the presence of I2 or Br2. The alpha -iodo- or alpha -bromo-amide is useful for making the alpha , beta -unsaturated amide through dehydrohalogenation.
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Inventors:
Anthony On-Ping King
Kevin Anderson
Thunder Karadi
Newton El. Abramson
Richard F. Schmann
Kevin Anderson
Thunder Karadi
Newton El. Abramson
Richard F. Schmann
Application Number:
JP21526691A
Publication Date:
June 29, 1994
Filing Date:
August 27, 1991
Export Citation:
Assignee:
Merck End-Campany Inc.
International Classes:
A61K31/395; C07C231/12; C07C233/04; C07D223/10; C07D223/16; C07D233/04; C07D233/10; C07D233/16; C07J51/00; C07J73/00; C07J75/00; (IPC1-7): C07C233/04; A61K31/395; C07C231/12; C07D233/04; C07D233/10; C07D233/16; C07J51/00; C07J73/00; C07J75/00
Attorney, Agent or Firm:
Masao Okabe (6 others)
Next Patent: ４，４′−ジニトロスチルベン−２，２′−ジスルホン酸の製造方法