Title:
【発明の名称】受容体の生物活性を調節するための化合物の能力を予測する方法
Document Type and Number:
Japanese Patent JP2002512368
Kind Code:
A
Abstract:
The ability of a query compound to modulate the biological activity of a receptor in a multicellular organism is predicted on the basis of its interaction with that receptor in the presence of various member of a panel of BioKeys. The BioKeys are ligands, especially peptides or nucleic acids, known to modify the conformation of the receptor. This interaction data, known as a "fingerprint", is compared to the fingerprints for reference compounds with known biological activities mediated by that receptor. In the "molecular braille" (MB) embodiment of the present invention, the reference and test fingerprints are based on in vitro (cell-free) assays. In the "cellular-braille" (CB) embodiment of the present invention, the reference and test fingerprints are based on cellular assays (but not on assays of whole multicellular organisms, or their organs or tissues).
Inventors:
Paige, Lisa A.
Hamilton, Paul T.
Foulkes, Dana Em.
Booler, benjamin
Barnet, Tom
McDonnell, Donald Py.
Christensen, Dale Jay
Hamilton, Paul T.
Foulkes, Dana Em.
Booler, benjamin
Barnet, Tom
McDonnell, Donald Py.
Christensen, Dale Jay
Application Number:
JP2000545020A
Publication Date:
April 23, 2002
Filing Date:
March 26, 1999
Export Citation:
Assignee:
Caro Bio Us A, Inc.
International Classes:
C07K1/04; C07K4/12; C07K7/08; G01N33/15; G01N33/50; G01N33/74; (IPC1-7): G01N33/74; C07K4/12; C07K7/08; G01N33/15; G01N33/50
Attorney, Agent or Firm:
Funakashi Eiko