Title:
【発明の名称】固体支持体上でのポリピロール及びポリイミダゾールカルボキサミドの合成方法
Document Type and Number:
Japanese Patent JP3231045
Kind Code:
B2
Abstract:
The present invention describes a novel method for the solid phase synthesis of polyamides containing imidazole and pyrrole carboxamides. The polyamides are prepared on a solid support from aromatic carboxylic acids and aromatic amines with high stepwise coupling yields (>99%), providing milligram quantities of highly pure polyamides. The present invention also describes the synthesis of analogs of the natural products Netropsin and Distamycin A, two antiviral antibiotics. The present invention also describes a novel method for the solid phase synthesis of imidazole and pyrrole carboxamide polyamide-oligonucleotide conjugates. This methodology will greatly increase both the complexity and quantity of minor-groove binding polyamides and minor-groove binding polyamide-oligonucleotide conjugates which can be synthesized and tested.
Inventors:
Delvan, Peter Bee.
Baird, Eldon Yee.
Baird, Eldon Yee.
Application Number:
JP53042597A
Publication Date:
November 19, 2001
Filing Date:
February 20, 1997
Export Citation:
Assignee:
California Institute of Technology
International Classes:
A61K47/48; C07D207/34; C12N15/09; C07D233/54; C07D233/90; C07D401/14; C07D403/14; C07D487/22; C07H21/00; C07K1/04; C07K5/078; C07K7/00; C07K7/02; C07K7/04; C07K17/08; C08G69/00; C12Q1/68; A61K38/00; (IPC1-7): C07D207/34; C07D233/90; C07D401/14
Domestic Patent References:
| JP3500773A |
Other References:
Ａｃｔａ Ｃｈｅｍｉｃａ Ｓｃａｎｄｉｎａｖｉｃａ，（１９９０），４４，ｐ６７−７４
Ｊ．Ｍｅｄ．Ｃｈｅｍ．，（１９９５），３８，，ｐ１１４０−１１４９
社団法人日本生化学会編「続生化学実験講座２ タンパク質の化学（下）」、第１版、株式会社東京化学同人、１９８７年５月２０日発行、ｐ６４１−６８０
Ｊ．Ｍｅｄ．Ｃｈｅｍ．，（１９９５），３８，，ｐ１１４０−１１４９
社団法人日本生化学会編「続生化学実験講座２ タンパク質の化学（下）」、第１版、株式会社東京化学同人、１９８７年５月２０日発行、ｐ６４１−６８０
Attorney, Agent or Firm:
Hidekazu Miyoshi (1 outside)
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