Title:
【発明の名称】局所使用されるジペプチジルペプチダーゼIVの新しいエフェクター
Document Type and Number:
Japanese Patent JP2003519099
Kind Code:
A
Abstract:
Amino acid cyclic amide derivatives (I) are new. Amino acid cyclic amide derivatives of formula (I) are new. B-A-C (I) A : an alpha -amino acid with a side-chain functional group; B : a molecule covalently bonded to the side-chain functional group of A, selected from oligopeptides with a chain length of up to 20 amino acids, polyethylene glycol (PEG) with a molecular weight of up to 20,000, optionally substituted organic amines, amides, alcohols, acids or aromatics with 8-50 C atoms; C : a thiazolidine (Thia), pyrrolidine, hydroxyproline, dehydroproline or piperidine group forming an amide bond with A. ACTIVITY : Antiinflammatory; antiallergic; dermatological; antiarthritic; antipsoriatic; immunomodulator; cytostatic. MECHANISM OF ACTION : Dipeptidyl peptidase IV (DP IV) modulator. The serum DP IV activity of rats after oral administration of 5 mu M Glu(PEG)-Thia was increased by almost 10% after 20 minutes and then decreased to 90% of the initial level over the next 100 minutes.
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Inventors:
Demus, Hans-Ulrich
Hoffman, Torsten
Schlenzig, Dagmar
Heiser, Ulrich
Hoffman, Torsten
Schlenzig, Dagmar
Heiser, Ulrich
Application Number:
JP2001518409A
Publication Date:
June 17, 2003
Filing Date:
August 20, 2000
Export Citation:
Assignee:
Probiodorg AG
International Classes:
A61K9/06; A61K8/49; A61K8/72; A61K9/08; A61K9/107; A61K9/12; A61K9/70; A61K9/72; A61K31/765; A61K38/00; A61K47/48; A61P1/02; A61P3/00; A61P17/00; A61P17/06; A61P19/02; A61P29/00; A61P35/00; A61P37/00; A61P37/06; A61P37/08; A61P43/00; C07K5/037; C07K5/06; C07K5/072; C07K5/083; C07K5/113; C07K7/06; C07K7/08; C08G65/329; (IPC1-7): A61K31/765; A61K7/00; A61K9/06; A61K9/08; A61K9/107; A61K9/12; A61K9/70; A61K9/72; A61K38/00; A61K47/48; A61P1/02; A61P17/00; A61P17/06; A61P19/02; A61P29/00; A61P35/00; A61P37/06; A61P37/08; A61P43/00; C07K5/113; C07K7/06; C08G65/329
Attorney, Agent or Firm:
Toshizo Iida