Title:
【発明の名称】タキソール類似体である新規な誘導体、その製造およびこれを含有する組成物
Document Type and Number:
Japanese Patent JPH06509107
Kind Code:
A
Abstract:
New derivatives of taxol analogues of general formula (I), their preparation and the compositions which contain them. In the formula (I): - Ar represents an aryl radical, - R represents a radical of general formula R7O- (II) in which R7 represents an optionally substituted alkyl radical or an alkenyl, alkynyl, cycloalkyl, cycloalkenyl, bicycloalkyl, phenyl or heterocyclyl radical, - R1 and R2, which are identical or different, represent a hydrogen atom or a radical of general formula (III) in which R3 and R4, which are identical or different, represent hydrogen or alkyl (optionally substituted by hydroxyl, carboxyl, alkyloxycarbonyl or a radical of formula (IV) in which R5 and R6, which are identical or different, represent hydrogen or alkyl or together form a 5- or 6-membered saturated or unsaturated heterocycle) or else R3 and R4 form a 5- or 6-membered, saturated or unsaturated heterocycle. The new products of formula (I) exhibit notable antitumour and antileukaemia properties.
Inventors:
BOURZAT JEAN-DOMINIQUE (FR)
COMMERCON ALAIN (FR)
GUENARD DANIEL (FR)
GUERITTE-VOEGELEIN FRANCOISE (FR)
POTIER PIERRE (FR)
COMMERCON ALAIN (FR)
GUENARD DANIEL (FR)
GUERITTE-VOEGELEIN FRANCOISE (FR)
POTIER PIERRE (FR)
Application Number:
JP50262993A
Publication Date:
October 13, 1994
Filing Date:
July 16, 1992
Export Citation:
Assignee:
RHONE POULENC RORER SA (FR)
International Classes:
C07D305/14; (IPC1-7): C07D305/14
Attorney, Agent or Firm:
Heikichi Odashima