Title:
【発明の名称】鎮痛性化合物およびその使用
Document Type and Number:
Japanese Patent JP2001526625
Kind Code:
A
Abstract:
The present invention discloses that compounds having the formula: wherein Z represents the atoms necessary to complete a five-membered or six-membered heterocyclic ring; D is a 1-piperid-4-yl moiety, a -Q-NH- moiety, or a -Q-S- moiety; Q is a bridging group; R1 is H, R3 or R4; R2is R3; each of A1 and A2 is H or A1 and A2 taken together form a second bond between the carbon atoms bearing A1 and A2; X is S, N-CN, CHNO2, O, or NH, provided that when D is a -Q-S- moiety, X is NH; R3 is selected from the group consisting of substituted or unsubstituted alkyls; substituted or unsubstituted 4-8-membered homocyclic rings; substituted or unsubstituted 4-8-membered heterocyclic rings; substituted or unsubstituted fused multicyclic rings; R4 is a moiety having the formula:-W-T-W- is -O-, -S-, -S-S-, -C(O)-O-, -C(O)-S-, -C(O)-N(R5)-, -N(R5)-, or CH=N-; T is selected from the group consisting of substituted or unsubstituted alkyls, substituted or unsubstituted 4-8-membered homocyclic rings, substituted or unsubstituted 4-8-membered heterocyclic rings, substituted or unsubstituted fused multicyclic rings, and proteinaceous transport vectors; R5 is H, substituted alkyl, or an unsubstituted alkyl and pharmaceutically acceptable salts thereof have analgesic activity. Methods for using these compounds in reducing pain and formulations containing and brain-penetrating derivatives of these compounds are also described.
Inventors:
Lindsay B. Huff
Application Number:
JP51892397A
Publication Date:
December 18, 2001
Filing Date:
November 08, 1996
Export Citation:
Assignee:
Albany Medical College
International Classes:
A61K31/34; A61K31/341; A61K31/4164; A61K31/426; A61K31/445; A61K31/4525; A61K31/454; A61P25/04; C07D233/64; C07D277/20; C07D277/36; C07D277/48; C07D307/52; C07D401/04; (IPC1-7): C07D233/64; A61K31/34; A61K31/4164; A61K31/426; A61K31/4525; A61K31/454; A61P25/04; A61P277/48; A61P307/52; A61P401/04
Attorney, Agent or Firm:
Ken Takahashi