Title:
【発明の名称】ヘッジホッグ蛋白質の薬学的組成物およびその使用
Document Type and Number:
Japanese Patent JP3092706
Kind Code:
B2
Abstract:
A pharmaceutical composition of a hedgehog protein which is characterized in that the hedgehog protein is bound to a hydrophilic carrier that is biocompatible and biodegradable wherein the carrier is a polymer which - binds the hedgehog protein as a negatively-charged carrier as a result of ionic interactions, - does not denature the hedgehog protein when it binds to the carrier, - contains at least 0.1 to 2 negatively-charged residues per monomer under neutral conditions, - contains the charge in the form of acidic groups, - has an average molecular weight of at least 50,000 Da - and contains no agarose reversibly and actively releases hedgehog proteins in vivo from a carrier in a delayed manner.
Inventors:
Kurt Lang
Apollo Papadimi treu
Apollo Papadimi treu
Application Number:
JP2783699A
Publication Date:
September 25, 2000
Filing Date:
February 04, 1999
Export Citation:
Assignee:
Roche Diagnostics Game Behr
International Classes:
A61K9/00; A61K9/16; A61K31/00; A61K35/12; A61K38/16; A61K38/00; A61K38/17; A61K38/18; A61K47/30; A61K47/36; A61K47/42; A61K47/48; A61P19/00; A61P19/08; C07K14/435; C07K14/47; C07K17/10; A61K; (IPC1-7): A61K38/00; A61K47/36; A61P19/00; C07K14/435; C07K17/10
Domestic Patent References:
| JP8231435A | ||||
| JP10167987A | ||||
| JP4244014A | ||||
| JP9194348A | ||||
| JP10194987A | ||||
| JP267300A | ||||
| JP4279520A | ||||
| JP9507853A | ||||
| JP6503358A |
Other References:
【文献】国際公開98/31345(WO,A1)
Attorney, Agent or Firm:
Shimizu Hatsushi (1 person outside)