Title:
【発明の名称】保護されていない7-α-ヒドロキシ基を有する中間体を使用する、7-α-ヒドロキシ3-アミノ置換ステロイドの調製のためのプロセス
Document Type and Number:
Japanese Patent JP2003531148
Kind Code:
A
Abstract:
An efficient method for the synthesis of aminosterol compounds such as squalamine and compound 1436 is described. A method of the invention provides for regioselective sulfonation of a fused ring system. The fused ring system base can be, for example, a steroid ring base. The aminosterol compounds are effective as, among others, antibiotics, antiangiogenic agents and NHE3 inhibitors.
Inventors:
Kinney, William A.
Zhang, Suhai
Michelard, Ronald
Zhang, Suhai
Michelard, Ronald
Application Number:
JP2001576852A
Publication Date:
October 21, 2003
Filing Date:
April 12, 2001
Export Citation:
Assignee:
Genera Corporation
International Classes:
C07B61/00; C07J9/00; C07J21/00; C07J31/00; C07J41/00; (IPC1-7): C07J9/00; C07J21/00; C07J41/00
Domestic Patent References:
| JPS568399A | 1981-01-28 |
Foreign References:
| WO1998024800A2 | 1998-06-11 |
Attorney, Agent or Firm:
Shusaku Yamamoto (2 outside)