Title:
【発明の名称】β-ラクタマーゼ阻害剤としての6β-置換ペニシラン酸
Document Type and Number:
Japanese Patent JPH10511076
Kind Code:
A
Abstract:
A 6 beta -substituted penicillanic acid of the formula XII: or a pharmaceutically acceptable salt or ester thereof, wherein A and B are each hydrogen wherein the carbon atoms to which A and B are attached are linked by a single bond, or A and B together form a bond, wherein the carbon atoms to which A and B are attached are linked by a double bond, R1 is selected from the group consisting of a) hydrogen, b) a pharmaceutically acceptable salt and c) a pharmaceutically acceptable group selected from the group consisting of C1-10 alkyl, C2-10 alkenyl, C2-10 alkynyl, C3-10 cycloalkyl, C3-10 cycloalkenyl, allyl, aryl, aralkyl, aralkenyl, aralkynyl, heterocyclyl, heterocyclylalkyl, heterocyclylalkenyl, heterocyclylalkynyl and alkylheterocyclyl; wherein said group c) is unsubstituted or substituted with a substituent selected from the group consisting of floro, chloro, bromo, iodo, azido, nitro, monoalkyl substituted amino, dialkyl substituted amino, aryl substituted amino, alkanoylamino, arylcarbonylamino, cyano, hydroxy, alkoxy, aryloxy, alkanoyloxy, arylcarbonyloxy, mercapto, alkylthio, arylthio, alkanoylthio, arylcarbonylthio, oxyimino, alkoxyimino and carboxy, and n is an integer between 0 and 2.
Inventors:
Noguchi Kazuharu
Mikety Ronald G.
Danesta Love Mosen
Mikety Ronald G.
Danesta Love Mosen
Application Number:
JP50636496A
Publication Date:
October 27, 1998
Filing Date:
August 03, 1995
Export Citation:
Assignee:
Sinfer Laboratories, Inc.
International Classes:
C07D499/10; A61K31/43; A61P31/04; C07D499/00; C07D499/70; C07D499/72; (IPC1-7): C07D499/70; A61K31/43; C07D499/10
Attorney, Agent or Firm:
Eiji Saegusa (2 others)